[Relationship between respiratory viral load of cases of COVID-19 and secondary attack risk in close contacts].
Zhonghua Liu Xing Bing Xue Za Zhi
; 42(6): 1008-1011, 2021 Jun 10.
Article
in Chinese
| MEDLINE | ID: covidwho-1314796
ABSTRACT
Objective:
To analyze the relationship between the cycle threshold (Ct) values of N gene of COVID-19 cases and the secondary attack risk in close contacts, and identify the relationship between respiratory viral load and infectivity in COVID-19 cases.Methods:
The COVID-19 cases with records of Ct values of N gene within 0-7 days of onset were selected, and their close contacts were recruited as the subjects of study. We collected the information of close contacts, including name, gender, age, isolation mode, exposure mode and outcome (whether they were infected with SARS-CoV-2 or not) and other variables. Multivariate logistic regression models were used to identify the relationship between Ct values of N gene of COVID-19 cases and secondary attack risk in close contacts.Results:
A total of 1 618 close contacts were recruited, in whom 77 were confirmed as symptomatic or asymptomatic COVID-19 patients with overall secondary attack rate of 4.8%. The multivariate logistic regression analysis indicated that eating together (OR=2.741, P=0.054), living together (OR=9.721, P<0.001), non-centralized isolation (OR=18.437, P<0.001) and COVID-19 case's values of N gene within 0-7 days of onset being <20 (OR=8.998, P=0.004) or 20-25 (OR=3.547, P=0.032) were significantly associated with higher likelihood of being infected with SARS-CoV-2 in close contacts.Conclusion:
The results indicated that positive relationship exists between respiratory viral load and infectivity in COVID-19 cases, suggesting that Ct values of N gene can be used as an early warning indicator for the management of close contacts of COVID-19 cases.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Viral Load
/
Coronavirus Nucleocapsid Proteins
/
COVID-19
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Zhonghua Liu Xing Bing Xue Za Zhi
Year:
2021
Document Type:
Article
Affiliation country:
Cma.j.cn112338-20210224-00141
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