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Can We Protect Those We Care for in A Pandemic? - Prevalence of Neutralizing Antibodies against SARS-CoV-2 in Nursing Homes.
Willschke, Harald; Wochele-Thoma, Thomas; Atanasov, Atanas G; Klager, Elisabeth; Haslinger, Christian; Kletecka-Pulker, Maria; Laxar, Daniel; Ay, Care; Öhlinger, Thomas; Kimberger, Oliver; Steinrigl, Adi; Holzer, Barbara; Heger, Florian; Indra, Alexander.
  • Willschke H; 1Ludwig Boltzmann Institute of Digital Health and Patient Safety, Vienna, Austria.
  • Wochele-Thoma T; 2Department of Anaesthesia and General Intensive Care, Medical University Vienna, Austria.
  • Atanasov AG; 1Ludwig Boltzmann Institute of Digital Health and Patient Safety, Vienna, Austria.
  • Klager E; 3Caritas Erzdiözese Wien, Vienna, Austria.
  • Haslinger C; 1Ludwig Boltzmann Institute of Digital Health and Patient Safety, Vienna, Austria.
  • Kletecka-Pulker M; 4Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, Magdalenka, Poland.
  • Laxar D; 5Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
  • Ay C; 6Department of Pharmacognosy, University of Vienna, Vienna, Austria.
  • Öhlinger T; 1Ludwig Boltzmann Institute of Digital Health and Patient Safety, Vienna, Austria.
  • Kimberger O; 7Hygienefachkraft-unlimited, Vienna, Austria.
  • Steinrigl A; 1Ludwig Boltzmann Institute of Digital Health and Patient Safety, Vienna, Austria.
  • Holzer B; 1Ludwig Boltzmann Institute of Digital Health and Patient Safety, Vienna, Austria.
  • Heger F; 2Department of Anaesthesia and General Intensive Care, Medical University Vienna, Austria.
  • Indra A; 2Department of Anaesthesia and General Intensive Care, Medical University Vienna, Austria.
Aging Dis ; 12(3): 710-717, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1315005
Semantic information from SemMedBD (by NLM)
1. Nursing Homes LOCATION_OF Work
Subject
Nursing Homes
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LOCATION_OF
Object
Work
2. Nursing Homes LOCATION_OF Study
Subject
Nursing Homes
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LOCATION_OF
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Study
3. 2019 novel coronavirus PROCESS_OF Persons
Subject
2019 novel coronavirus
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PROCESS_OF
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Persons
4. Nursing Homes LOCATION_OF Analysis
Subject
Nursing Homes
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LOCATION_OF
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Analysis
5. Antibodie PART_OF C0027361
Subject
Antibodie
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PART_OF
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C0027361
6. Health care facility LOCATION_OF Study
Subject
Health care facility
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LOCATION_OF
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7. Nursing Homes LOCATION_OF Work
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Nursing Homes
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LOCATION_OF
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Work
8. Nursing Homes LOCATION_OF Study
Subject
Nursing Homes
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LOCATION_OF
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9. 2019 novel coronavirus PROCESS_OF Persons
Subject
2019 novel coronavirus
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PROCESS_OF
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Persons
10. Nursing Homes LOCATION_OF Analysis
Subject
Nursing Homes
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LOCATION_OF
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11. Antibodies, Neutralizing PART_OF Persons
Subject
Antibodies, Neutralizing
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PART_OF
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Persons
12. Health care facility LOCATION_OF Study
Subject
Health care facility
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LOCATION_OF
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Study
ABSTRACT
In December 2019, the People's Republic of China and the World Health Organization first reported on a cluster of pneumonia with an unknown cause. Nine months later more than 1.4 million people have died from COVID 19. In this work, the effects of the COVID 19 pandemic on five nursing homes in Austria, which cared for 889 residents in the first half of 2020, were examined. The research question was whether the measures taken were appropriate to prevent an outbreak within the individual facilities. To detect previously unrecognized infections, the present study evaluated the prevalence of neutralizing antibodies against the SARS-CoV-2 virus in residents and employees of the nursing homes. Following the analysis of blood samples, the prospectively collected data was connected to data from screening examinations and data from contact tracing. The present study demonstrated an overall prevalence of neutralizing antibodies against the SARS-CoV-2 virus in nursing homes of 3.7%. Whereas the prevalence in those facilities that have never been hit by an outbreak is 0%, the prevalence in those facilities with an outbreak is up to 4.9%. Neutralizing antibodies against SARS-CoV-2 were detected in 35 persons. A retrospective analysis of all 5 included nursing homes demonstrated that upon regular clinical screening in combination with PCRs an infection with SARS-COV-2 was detected in 66 residents and 24 employees from different professional groups. In only 25 of the 35 persons with neutralizing antibodies against SARS-CoV-2 an infection was proven in advance. This study suggests that specific measures can prevent transmission within a health care facility. Nevertheless, the results also show that a risk reduction to 0% cannot be achieved. In preparation for further pandemic waves there is still the need to reduce the probability of a transmission in nursing homes with specific test strategies.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Aging Dis Year: 2021 Document Type: Article Affiliation country: Ad.2021.0217

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Aging Dis Year: 2021 Document Type: Article Affiliation country: Ad.2021.0217