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Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets.
Francis, Magen E; Richardson, Brian; Goncin, Una; McNeil, Mara; Rioux, Melissa; Foley, Mary K; Ge, Anni; Pechous, Roger D; Kindrachuk, Jason; Cameron, Cheryl M; Richardson, Christopher; Lew, Jocelyne; Machtaler, Steven; Cameron, Mark J; Gerdts, Volker; Falzarano, Darryl; Kelvin, Alyson A.
  • Francis ME; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Richardson B; Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada.
  • Goncin U; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • McNeil M; Department of Medical Imaging, University of Saskatchewan, Saskatoon, SK, S7N 0W8, Canada.
  • Rioux M; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Foley MK; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Ge A; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Pechous RD; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Kindrachuk J; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AK, 72205, USA.
  • Cameron CM; Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada.
  • Richardson C; Laboratory of Emerging and Re-emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada.
  • Lew J; Department of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Machtaler S; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
  • Cameron MJ; Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada.
  • Gerdts V; Department of Medical Imaging, University of Saskatchewan, Saskatoon, SK, S7N 0W8, Canada.
  • Falzarano D; Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Kelvin AA; Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, S7N 5E3, Canada.
Sci Rep ; 11(1): 14536, 2021 07 15.
Article in English | MEDLINE | ID: covidwho-1315609
ABSTRACT
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) hospitalizations and deaths disportionally affect males and older ages. Here we investigated the impact of male sex and age comparing sex-matched or age-matched ferrets infected with SARS-CoV-2. Differences in temperature regulation was identified for male ferrets which was accompanied by prolonged viral replication in the upper respiratory tract after infection. Gene expression analysis of the nasal turbinates indicated that 1-year-old female ferrets had significant increases in interferon response genes post infection which were delayed in males. These results provide insight into COVID-19 and suggests that older males may play a role in viral transmission due to decreased antiviral responses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferons / Ferrets / COVID-19 Limits: Animals Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-93855-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interferons / Ferrets / COVID-19 Limits: Animals Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-93855-9