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Coronary artery calcium score may be a novel predictor of COVID-19 prognosis: a retrospective study.
Takeshita, Yuichiro; Terada, Jiro; Fujita, Retsu; Hirasawa, Yasutaka; Kinoshita, Taku; Isaka, Yuri; Kinouchi, Toru; Tajima, Hiroshi; Tada, Yuji; Kiryu, Shigeru; Tsushima, Kenji.
  • Takeshita Y; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Terada J; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan jirotera@iuhw.ac.jp.
  • Fujita R; Innovation and Research Support Center, International University of Health and Welfare, Tokyo, Japan.
  • Hirasawa Y; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Kinoshita T; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Isaka Y; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Kinouchi T; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Tajima H; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Tada Y; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Kiryu S; Department of Radiology, International University of Health and Welfare Narita Hospital, Narita, Japan.
  • Tsushima K; Department of Pulmonary Medicine, International University of Health and Welfare Narita Hospital, Narita, Japan.
BMJ Open Respir Res ; 8(1)2021 07.
Article in English | MEDLINE | ID: covidwho-1315812
ABSTRACT

BACKGROUND:

Although several studies have reported an association between atherosclerosis-related diseases and COVID-19, the relationship between COVID-19 severity and atherosclerosis progression remains unclear. The aim of this study is to determine the coronary artery calcium score (CACS) prognostic value in patients with COVID-19 using indices such as deterioration in oxygenation and CT images of the chest.

METHODS:

This was a single-centre retrospective study of 53 consecutive patients with COVID-19 in Narita who were admitted to our hospital between March 2020 and August 2020. CACS was calculated based on non-gated CT scans of the chest performed on admission day. The patients were divided into the following two groups based on CACS group 1 (CACS ≥180, n=11) and group 2 (CACS <180, n=42). Following univariate analysis of the main variables, multivariate analysis of variables that may be associated with COVID-19 progression was performed.

RESULTS:

Multivariable logistic regression analysis of age, sex, smoking history, diabetes, hypertension, dyslipidaemia, number of days from symptom onset to hospitalisation and CACS of ≥180 was performed. It revealed that unlike CACS of <180, CACS of ≥180 is associated with exacerbation of oxygenation or CT images of the chest during hospitalisation (OR 12.879, 95% CI 1.399 to 380.401). Furthermore, this model of eight variables showed good calibration (Hosmer-Lemeshow p=0.119).

CONCLUSION:

CACS may be a prognosis marker of COVID-19 severity. Although coronary artery calcification is not typically assessed in pneumonia cases, it may provide a valuable clinical indicator for predicting severe COVID-19 outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronary Artery Disease / Vascular Calcification / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bmjresp-2021-000923

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Coronary Artery Disease / Vascular Calcification / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2021 Document Type: Article Affiliation country: Bmjresp-2021-000923