The Role of PCSK9 in Infectious Diseases.
Curr Med Chem
; 29(6): 1000-1015, 2022.
Article
in English
| MEDLINE | ID: covidwho-2270303
ABSTRACT
BACKGROUND:
In recent years, many aspects of the physiological role of PCSK9 have been elucidated, in particular regarding its role in lipid metabolism, cardiovascular risk but also its role in innate immunity. Increasing evidence is available on the involvement of PCSK9 in the pathogenesis of viral infections, mainly HCV, as well as in the regulation of host response to bacterial infections, mainly sepsis and septic shock. Moreover, the action of PCSK9 has been investigated as a crucial step in the pathogenesis of malaria infection and disease severity.OBJECTIVE:
Aim of this paper is to review available published literature on the role of PCSK9 in a wide array of infectious diseases.CONCLUSION:
Besides the ongoing investigation on PCSK9 inhibition among HIV-infected patients for the treatment of HIV- and ART-related hyperlipidemia, preclinical studies indicate how PCSK9 is involved in reducing the replication of HCV. Moreover, a protective role of PCSK9 inhibition has also been proposed against dengue and SARS-CoV-2 viral infections. Interestingly, high plasmatic PCSK9 levels have been described in patients with sepsis. Finally, a loss of function in the PCSK9-encoding gene has been reported to possibly reduce mortality in malaria infection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Communicable Diseases
/
Proprotein Convertase 9
/
COVID-19
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Curr Med Chem
Journal subject:
Chemistry
Year:
2022
Document Type:
Article
Affiliation country:
0929867328666210714160343
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