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The Gut Microbiota of Critically Ill Patients With COVID-19.
Gaibani, Paolo; D'Amico, Federica; Bartoletti, Michele; Lombardo, Donatella; Rampelli, Simone; Fornaro, Giacomo; Coladonato, Simona; Siniscalchi, Antonio; Re, Maria Carla; Viale, Pierluigi; Brigidi, Patrizia; Turroni, Silvia; Giannella, Maddalena.
  • Gaibani P; Microbiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, IRCCS St. Orsola Hospital and University of Bologna, Bologna, Italy.
  • D'Amico F; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
  • Bartoletti M; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Lombardo D; Infectious Diseases Unit, Department of Medical and Surgical Sciences, IRCCS St. Orsola Hospital, Bologna, Italy.
  • Rampelli S; Microbiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, IRCCS St. Orsola Hospital and University of Bologna, Bologna, Italy.
  • Fornaro G; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
  • Coladonato S; Infectious Diseases Unit, Department of Medical and Surgical Sciences, IRCCS St. Orsola Hospital, Bologna, Italy.
  • Siniscalchi A; Infectious Diseases Unit, Department of Medical and Surgical Sciences, IRCCS St. Orsola Hospital, Bologna, Italy.
  • Re MC; Intensive Care Unit, Department of Medical and Surgical Sciences, IRCCS St. Orsola Hospital and University of Bologna, Bologna, Italy.
  • Viale P; Microbiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, IRCCS St. Orsola Hospital and University of Bologna, Bologna, Italy.
  • Brigidi P; Infectious Diseases Unit, Department of Medical and Surgical Sciences, IRCCS St. Orsola Hospital, Bologna, Italy.
  • Turroni S; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Giannella M; Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy.
Front Cell Infect Microbiol ; 11: 670424, 2021.
Article in English | MEDLINE | ID: covidwho-1315951
ABSTRACT
The SARS-CoV-2-associated COVID-19 pandemic has shaken the global healthcare system. Although the best-known symptoms are dry cough and pneumonia, viral RNA has been detected in the stool and about half of COVID-19 patients exhibit gastrointestinal upset. In this scenario, special attention is being paid to the possible role of the gut microbiota (GM). Fecal samples from 69 COVID-19 patients from three different hospitals of Bologna (Italy) were analyzed by 16S rRNA gene-based sequencing. The GM profile was compared with the publicly available one of healthy age- and gender-matched Italians, as well as with that of other critically ill non-COVID-19 patients. The GM of COVID-19 patients appeared severely dysbiotic, with reduced diversity, loss of health-associated microorganisms and enrichment of potential pathogens, particularly Enterococcus. This genus was far overrepresented in patients developing bloodstream infections (BSI) and admitted to the intensive care unit, while almost absent in other critically ill non-COVID-19 patients. Interestingly, the percentage of patients with BSI due to Enterococcus spp. was significantly higher during the COVID-19 pandemic than in the previous 3 years. Monitoring the GM of critically ill COVID-19 patients could help clinical management, by predicting the onset of medical complications such as difficult-to-treat secondary infections.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.670424

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / COVID-19 Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.670424