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Topical Oral and Intranasal Antiviral Agents for Coronavirus Disease 2019 (COVID-19).
Hsue, Victor B; Itamura, Kyohei; Wu, Arthur W; Illing, Elisa A; Sokoloski, Kevin J; Weaver, Bree A; Anthony, Benjamin P; Hughes, Nathan; Ting, Jonathan Y; Higgins, Thomas S.
  • Hsue VB; Department of Otolaryngology-Head and Neck Surgery, Cedars Sinai, Los Angeles, CA, USA.
  • Itamura K; Department of Otolaryngology-Head and Neck Surgery, Cedars Sinai, Los Angeles, CA, USA.
  • Wu AW; Department of Otolaryngology-Head and Neck Surgery, Cedars Sinai, Los Angeles, CA, USA.
  • Illing EA; Department of Otolaryngology-Head and Neck Surgery, Indiana University, Indianapolis, IN, USA.
  • Sokoloski KJ; Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.
  • Weaver BA; Division of Infectious Diseases, Departments of Internal Medicine and Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
  • Anthony BP; Department of Otolaryngology-Head and Neck Surgery, Indiana University, Indianapolis, IN, USA.
  • Hughes N; Pharmacy Operations, Kindred Healthcare Support Center, Louisville, KY, USA.
  • Ting JY; Department of Otolaryngology-Head and Neck Surgery, Indiana University, Indianapolis, IN, USA.
  • Higgins TS; Department of Otolaryngology-Head and Neck Surgery and Communicative Disorders, University of Louisville, Louisville, KY, USA. thomas.higgins@louisville.edu.
Adv Exp Med Biol ; 1327: 169-189, 2021.
Article in English | MEDLINE | ID: covidwho-1316247
ABSTRACT
With the largest viral loads in both symptomatic and asymptomatic patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) present in the oral and nasal cavities, agents that act on these two areas have the potential for large therapeutic and prophylactic benefit. A literature review was conducted to elucidate the possible agents useful in treatment of SARS-CoV-2. These agents were evaluated for their current applications, adverse reactions, their current state of study, and any future considerations in their management of coronavirus disease 2019 (COVID-2019). Our review has found that, while there are many promising agents with proven efficacy in their in-vitro efficacy against SARS-CoV-2, more clinical trials and in-vivo studies, as well as safety trials, must be conducted before these agents can be effectively implemented.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Reviews Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2021 Document Type: Article Affiliation country: 978-3-030-71697-4_14

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Reviews Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2021 Document Type: Article Affiliation country: 978-3-030-71697-4_14