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Comparison of Clinical Characteristics Among COVID-19 and Non-COVID-19 Pediatric Pneumonias: A Multicenter Cross-Sectional Study.
Jia, Zhongwei; Yan, Xiangyu; Gao, Liwei; Ding, Shenggang; Bai, Yan; Zheng, Yuejie; Cui, Yuxia; Wang, Xianfeng; Li, Jingfeng; Lu, Gen; Xu, Yi; Zhang, Xiangyu; Li, Junhua; Chen, Ning; Shang, Yunxiao; Han, Mingfeng; Liu, Jun; Zhou, Hourong; Li, Cen; Lu, Wanqiu; Liu, Jun; Wang, Lina; Fan, Qihong; Wu, Jiang; Shen, Hanling; Jiao, Rong; Chen, Chunxi; Gao, Xiaoling; Tian, Maoqiang; Lu, Wei; Yang, Yonghong; Wong, Gary Wing-Kin; Wang, Tianyou; Jin, Runming; Shen, Adong; Xu, Baoping; Shen, Kunling.
  • Jia Z; School of Public Health, Peking University, Beijing, China.
  • Yan X; Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing, China.
  • Gao L; Center for Drug Abuse Control and Prevention, National Institute of Health Data Science, Peking University, Beijing, China.
  • Ding S; School of Public Health, Peking University, Beijing, China.
  • Bai Y; Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing, China.
  • Zheng Y; Center for Drug Abuse Control and Prevention, National Institute of Health Data Science, Peking University, Beijing, China.
  • Cui Y; China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
  • Wang X; Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China.
  • Li J; Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Lu G; Pediatric Department, Union Hospital, Tongji Medical College, Huazhong University of Science And Technology, Hubei, China.
  • Xu Y; Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, China.
  • Zhang X; Department of Pediatrics, Guizhou Provincial People's Hospital, Guizhou, China.
  • Li J; Department of Pediatrics, Shenzhen Third People's Hospital, Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China.
  • Chen N; Department of Pediatrics, Taihe Hospital, Shiyan, China.
  • Shang Y; Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Han M; Department of Pediatric, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
  • Liu J; School of Public Health, Peking University, Beijing, China.
  • Zhou H; Center for Intelligent Public Health, Institute for Artificial Intelligence, Peking University, Beijing, China.
  • Li C; Center for Drug Abuse Control and Prevention, National Institute of Health Data Science, Peking University, Beijing, China.
  • Lu W; Department of Pediatrics, Xiangyang Central Hospital, Xiangyang, China.
  • Liu J; Department of Pediatric, Shengjing Hospital of China Medical University, Liaoning, China.
  • Wang L; Department of Pediatric, Shengjing Hospital of China Medical University, Liaoning, China.
  • Fan Q; Department of Respiratory Medicine, The Second People's Hospital of Fuyang, Anhui, China.
  • Wu J; Department of Pediatrics, The People Hospital of Bozhou, Anhui, China.
  • Shen H; Department of General Practice, Guizhou Provincial People's Hospital, Guiyang, Guizhou, China.
  • Jiao R; Office of Academic Research, Jiangjunshan Hospital, Guizhou, China.
  • Chen C; Department of Pediatrics, Guizhou Provincial People's Hospital, Guizhou, China.
  • Gao X; Department of Pediatrics, The Affiliated Hospital of Guizhou University, Guizhou, China.
  • Tian M; China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
  • Lu W; Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China.
  • Yang Y; China National Clinical Research Center for Respiratory Diseases, Department of Respiratory Medicine, Beijing Children's Hospital, National Center for Children's Health, Capital Medical University, Beijing, China.
  • Wong GW; Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, Beijing, China.
  • Wang T; Department of Pediatrics, Jingzhou First People's Hospital, Jingzhou, China.
  • Jin R; Department of Pediatrics, Huangshi Maternity and Child Health Care Hospital, Huangshi, China.
  • Shen A; Department of Pediatrics, Suizhou Maternity and Child Health Care Hospital, Suizhou, China.
  • Xu B; Department of Pediatrics, Xiangyang First People's Hospital, Xiangyang, China.
  • Shen K; Department of Pediatrics, Xishui People's Hospital, Huanggang, China.
Front Cell Infect Microbiol ; 11: 663884, 2021.
Article in English | MEDLINE | ID: covidwho-1317217
ABSTRACT

Background:

The pandemic of Coronavirus Disease 2019 (COVID-19) brings new challenges for pediatricians, especially in the differentiation with non-COVID-19 pneumonia in the peak season of pneumonia. We aimed to compare the clinical characteristics of pediatric patients with COVID-19 and other respiratory pathogens infected pneumonias.

Methods:

We conducted a multi-center, cross-sectional study of pediatric inpatients in China. Based on pathogenic test results, pediatric patients were divided into three groups, including COVID-19 pneumonia group, Non-COVID-19 viral (NCV) pneumonia group and Non-viral (NV) pneumonia group. Their clinical characteristics were compared by Kruskal-Wallis H test or chi-square test.

Results:

A total of 636 pediatric pneumonia inpatients, among which 87 in COVID-19 group, 194 in NCV group, and 355 in NV group, were included in analysis. Compared with NCV and NV patients, COVID-19 patients were older (median age 6.33, IQR 2.00-12.00 years), and relatively fewer COVID-19 patients presented fever (63.2%), cough (60.9%), shortness of breath (1.1%), and abnormal pulmonary auscultation (18.4%). The results were verified by the comparison of COVID-19, respiratory syncytial virus (RSV) and influenza A (IFA) pneumonia patients. Approximately 42.5%, 44.8%, and 12.6% of the COVID-19 patients presented simply ground-glass opacity (GGO), simply consolidation, and the both changes on computed tomography (CT) scans, respectively; the proportions were similar as those in NCV and NV group (p>0.05). Only 47.1% of COVID-19 patients had both lungs pneumonia, which was significantly lower than that proportion of nearly 80% in the other two groups. COVID-19 patients presented lower proportions of increased white blood cell count (16.5%) and abnormal procalcitonin (PCT) (10.7%), and a higher proportion of decreased lymphocyte count (44.0%) compared with the other two groups.

Conclusion:

Majority clinical characteristics of pediatric COVID-19 pneumonia patients were milder than non-COVID-19 patients. However, lymphocytopenia remained a prominent feature of COVID-19 pediatric pneumonia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.663884

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Child / Humans Country/Region as subject: Asia Language: English Journal: Front Cell Infect Microbiol Year: 2021 Document Type: Article Affiliation country: Fcimb.2021.663884