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Spectrum of Endocrine Dysfunction and Association With Disease Severity in Patients With COVID-19: Insights From a Cross-Sectional, Observational Study.
Das, Liza; Dutta, Pinaki; Walia, Rama; Mukherjee, Soham; Suri, Vikas; Puri, Goverdhan Dutt; Mahajan, Varun; Malhotra, Pankaj; Chaudhary, Shakun; Gupta, Rahul; Jayant, Satyam Singh; Agrawal, Kanhaiya; Kumar, Vijay; Sachdeva, Naresh; Rastogi, Ashu; Bhadada, Sanjay Kumar; Ram, Sant; Bhansali, Anil.
  • Das L; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Dutta P; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Walia R; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Mukherjee S; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Suri V; Department of Internal Medicine, PGIMER, Chandigarh, India.
  • Puri GD; Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh, India.
  • Mahajan V; Department of Anaesthesia and Intensive Care, PGIMER, Chandigarh, India.
  • Malhotra P; Department of Haematology, PGIMER, Chandigarh, India.
  • Chaudhary S; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Gupta R; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Jayant SS; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Agrawal K; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Kumar V; Department of Internal Medicine, PGIMER, Chandigarh, India.
  • Sachdeva N; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Rastogi A; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Bhadada SK; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
  • Ram S; Department of Biochemistry, PGIMER, Chandigarh, India.
  • Bhansali A; Department of Endocrinology, Post Graduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.
Front Endocrinol (Lausanne) ; 12: 645787, 2021.
Article in English | MEDLINE | ID: covidwho-1317220
ABSTRACT

Introduction:

Evidence on new-onset endocrine dysfunction and identifying whether the degree of this dysfunction is associated with the severity of disease in patients with COVID-19 is scarce. Patients and

Methods:

Consecutive patients enrolled at PGIMER Chandigarh were stratified on the basis of disease severity as group I (moderate-to-severe disease including oxygen saturation <94% on room air or those with comorbidities) (n= 35) and group II (mild disease, with oxygen saturation >94% and without comorbidities) (n=49). Hypothalamo-pituitary-adrenal, thyroid, gonadal axes, and lactotroph function were evaluated. Inflammatory and cell-injury markers were also analysed.

Results:

Patients in group I had higher prevalence of hypocortisolism (38.5 vs 6.8%, p=0.012), lower ACTH (16.3 vs 32.1pg/ml, p=0.234) and DHEAS (86.29 vs 117.8µg/dl, p= 0.086) as compared to group II. Low T3 syndrome was a universal finding, irrespective of disease severity. Sick euthyroid syndrome (apart from low T3 syndrome) (80.9 vs 73.1%, p= 0.046) and atypical thyroiditis (low T3, high T4, low or normal TSH) (14.3 vs 2.4%, p= 0.046) were more frequent in group I than group II. Male hypogonadism was also more prevalent in group I (75.6% vs 20.6%, p=0.006) than group II, with higher prevalence of both secondary (56.8 vs 15.3%, p=0.006) and primary (18.8 vs 5.3%, p=0.006) hypogonadism. Hyperprolactinemia was observed in 42.4% of patients without significant difference between both groups.

Conclusion:

COVID-19 can involve multiple endocrine organs and axes, with a greater prevalence and degree of endocrine dysfunction in those with more severe disease.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endocrine System Diseases / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.645787

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endocrine System Diseases / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Front Endocrinol (Lausanne) Year: 2021 Document Type: Article Affiliation country: Fendo.2021.645787