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[Clinical and morphological characteristics of SARS-CoV-2-related myocarditis proven by the presence of viral RNA and proteins in myocardial tissue]. / Kliniko-morfologicheskaya kharakteristika SARS-CoV-2-assotsiirovannogo miokardita, podtverzhdennogo nalichiem RNK i belkov virusa v tkani miokarda.
Kogan, E A; Kukleva, A D; Berezovskiy, Yu S; Blagova, O V; Zharkov, N V; Ainetdinova, D Kh; Demyashkin, G A.
  • Kogan EA; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia.
  • Kukleva AD; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia.
  • Berezovskiy YS; Central Research Institute of Tuberculosis, Moscow, Russia.
  • Blagova OV; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia.
  • Zharkov NV; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia.
  • Ainetdinova DK; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia.
  • Demyashkin GA; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of Russia, Moscow, Russia.
Arkh Patol ; 83(4): 5-13, 2021.
Article in Russian | MEDLINE | ID: covidwho-1317354
ABSTRACT

OBJECTIVE:

To investigate the clinical and morphological features of SARS-CoV-2-related myocarditis, by determining the presence of viral RNA and proteins in myocardial tissue. MATERIAL AND

METHODS:

The study was conducted to examine the material of 32 autopsies with a confirmed diagnosis of myocarditis. There were data of a morphological study, including a standard histological study, as well as immunohistochemical determination of the surface markers CD45, CD3, CD20, and CD68 cells of an inflammatory infiltrate and virus proteins (SARS-CoV-2 nucleocapsid protein and spike protein). Positive and negative control tests were carried out. In addition, coronavirus RNA was detected in the myocardium using a polymerase chain reaction.

RESULTS:

Polymerase chain reaction (PCR) revealed viral RNA in myocardial tissue. Viral proteins were identified in the macrophages of an inflammatory infiltrate and cardiomyocytes.

CONCLUSION:

The findings may suggest that the virus persists in the myocardium and chronic myocarditis develops.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Myocarditis Type of study: Prognostic study Limits: Humans Language: Russian Journal: Arkh Patol Year: 2021 Document Type: Article Affiliation country: Patol2021830415

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Myocarditis Type of study: Prognostic study Limits: Humans Language: Russian Journal: Arkh Patol Year: 2021 Document Type: Article Affiliation country: Patol2021830415