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High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients.
Yildiz, Eren; Cigri, Emrah; Dincer, Zubeyde; Narsat, Mehmet Ali; Calisir, Busra.
  • Yildiz E; Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey.
  • Cigri E; Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey.
  • Dincer Z; Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey.
  • Calisir B; Department of Microbiology, Kastamonu Training and Research Hospital, Kastamonu, Turkey.
J Coll Physicians Surg Pak ; 31(7): S93-S98, 2021 07.
Article in English | MEDLINE | ID: covidwho-1317395
ABSTRACT

OBJECTIVE:

To investigate the symptoms and laboratory results of children hospitalised with the diagnosis of COVID-19, aiming to reveal the characteristics of symptomatic cases. STUDY

DESIGN:

A descriptive cross-sectional study. PLACE AND DURATION OF STUDY Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey from March to December 2020.

METHODOLOGY:

Seventy-nine children, hospitalised with the diagnosis of COVID-19, were included in the study and were divided into two groups as symptomatic and asymptomatic. The demographic data, laboratory results and clinics of the patients of the two groups were compared.

RESULTS:

The mean age of participants was 10.43 ± 5.91 (0-17) years, and 57% (n=45) of them were girls. Five patients in the symptomatic group had comorbidities (2 allergic asthmacerebral palsy, type-1 diabetes mellitus and anorexia nervosa). The most common symptom was fever (36.7%, n=29). It was noteworthy that everyone with an NLR >3.13 (high-NLR) was symptomatic. Significantly more patients in the high-NLR group were symptomatic compared with the low-NLR group (p=0.005). On the other hand, symptomatic children had significantly higher levels of C-reactive protein (2.8 (IQR 1.2-10.0) mg/L vs. 1.4 (IQR 0.4-2.0) mg/L, p=0.011); and procalcitonin (0.05 (IQR 0.02-0.10) ng/mL vs. 0.01 (IQR 0.00-0.03) ng/mL, p<0.001) than those without symptoms. One of the children with cerebral palsy died from pneumonia during the study.

CONCLUSION:

C-reactive protein, procalcitonin and NLR levels were found to be significantly higher in symptomatic children. NLR can be suggested as a potential marker associated with disease severity in COVID-19 patients, which needs to be supported by other studies. Key Words COVID-19, Children, Neutrophil / lymphocyte ratio, C-reactive protein, Procalcitonin.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pediatrics / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: J Coll Physicians Surg Pak Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Jcpsp.2021.Supp2.S93

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pediatrics / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: J Coll Physicians Surg Pak Journal subject: Medicine Year: 2021 Document Type: Article Affiliation country: Jcpsp.2021.Supp2.S93