High Neutrophil/Lymphocyte Ratios in Symptomatic Pediatric COVID-19 Patients.
J Coll Physicians Surg Pak
; 31(7): S93-S98, 2021 07.
Article
in English
| MEDLINE | ID: covidwho-1317395
ABSTRACT
OBJECTIVE:
To investigate the symptoms and laboratory results of children hospitalised with the diagnosis of COVID-19, aiming to reveal the characteristics of symptomatic cases. STUDYDESIGN:
A descriptive cross-sectional study. PLACE AND DURATION OF STUDY Department of Pediatrics, Kastamonu Training and Research Hospital, Kastamonu, Turkey from March to December 2020.METHODOLOGY:
Seventy-nine children, hospitalised with the diagnosis of COVID-19, were included in the study and were divided into two groups as symptomatic and asymptomatic. The demographic data, laboratory results and clinics of the patients of the two groups were compared.RESULTS:
The mean age of participants was 10.43 ± 5.91 (0-17) years, and 57% (n=45) of them were girls. Five patients in the symptomatic group had comorbidities (2 allergic asthma, cerebral palsy, type-1 diabetes mellitus and anorexia nervosa). The most common symptom was fever (36.7%, n=29). It was noteworthy that everyone with an NLR >3.13 (high-NLR) was symptomatic. Significantly more patients in the high-NLR group were symptomatic compared with the low-NLR group (p=0.005). On the other hand, symptomatic children had significantly higher levels of C-reactive protein (2.8 (IQR 1.2-10.0) mg/L vs. 1.4 (IQR 0.4-2.0) mg/L, p=0.011); and procalcitonin (0.05 (IQR 0.02-0.10) ng/mL vs. 0.01 (IQR 0.00-0.03) ng/mL, p<0.001) than those without symptoms. One of the children with cerebral palsy died from pneumonia during the study.CONCLUSION:
C-reactive protein, procalcitonin and NLR levels were found to be significantly higher in symptomatic children. NLR can be suggested as a potential marker associated with disease severity in COVID-19 patients, which needs to be supported by other studies. Key Words COVID-19, Children, Neutrophil / lymphocyte ratio, C-reactive protein, Procalcitonin.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pediatrics
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
J Coll Physicians Surg Pak
Journal subject:
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Jcpsp.2021.Supp2.S93
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