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The efficacy of ultraviolet light-emitting technology against coronaviruses: a systematic review.
Chiappa, F; Frascella, B; Vigezzi, G P; Moro, M; Diamanti, L; Gentile, L; Lago, P; Clementi, N; Signorelli, C; Mancini, N; Odone, A.
  • Chiappa F; School of Public Health, University Vita-Salute San Raffaele, Milan, Italy.
  • Frascella B; School of Public Health, University Vita-Salute San Raffaele, Milan, Italy.
  • Vigezzi GP; School of Public Health, University Vita-Salute San Raffaele, Milan, Italy.
  • Moro M; Infection Control Committee, IRCCS San Raffaele Hospital, Milan, Italy.
  • Diamanti L; Clinical Engineering Unit, IRCCS San Raffaele Hospital, Milan, Italy; HTA Committee, IRCCS San Raffaele Hospital, Milan, Italy.
  • Gentile L; Clinical Engineering Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Lago P; Clinical Engineering Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
  • Clementi N; Laboratory of Microbiology and Virology, University Vita-Salute San Raffaele, Milan, Italy.
  • Signorelli C; School of Medicine, University Vita-Salute San Raffaele, Milan, Italy.
  • Mancini N; Laboratory of Microbiology and Virology, University Vita-Salute San Raffaele, Milan, Italy.
  • Odone A; HTA Committee, IRCCS San Raffaele Hospital, Milan, Italy; Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. Electronic address: anna.odone@unipv.it.
J Hosp Infect ; 114: 63-78, 2021 Aug.
Article in English | MEDLINE | ID: covidwho-1317467
ABSTRACT
The ongoing pandemic of COVID-19 has underlined the importance of adopting effective infection prevention and control (IPC) measures in hospital and community settings. Ultraviolet (UV)-based technologies represent promising IPC tools their effective application for sanitation has been extensively evaluated in the past but scant, heterogeneous and inconclusive evidence is available on their effect on SARS-CoV-2 transmission. With the aim of pooling the available evidence on the efficacy of UV technologies against coronaviruses, we conducted a systematic review following PRISMA guidelines, searching Medline, Embase and the Cochrane Library, and the main clinical trials' registries (WHO ICTRP, ClinicalTrials.gov, Cochrane and EU Clinical Trial Register). Quantitative data on studies' interventions were summarized in tables, pooled by different coronavirus species and strain, UV source, characteristics of UV light exposure and outcomes. Eighteen papers met our inclusion criteria, published between 1972 and 2020. Six focused on SARS-CoV-2, four on SARS-CoV-1, one on MERS-CoV, three on seasonal coronaviruses, and four on animal coronaviruses. All were experimental studies. Overall, despite wide heterogenicity within included studies, complete inactivation of coronaviruses on surfaces or aerosolized, including SARS-CoV-2, was reported to take a maximum exposure time of 15 min and to need a maximum distance from the UV emitter of up to 1 m. Advances in UV-based technologies in the field of sanitation and their proved high virucidal potential against SARS-CoV-2 support their use for IPC in hospital and community settings and their contribution towards ending the COVID-19 pandemic. National and international guidelines are to be updated and parameters and conditions of use need to be identified to ensure both efficacy and safety of UV technology application for effective infection prevention and control in both healthcare and non-healthcare settings.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ultraviolet Rays / Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Animals / Humans Language: English Journal: J Hosp Infect Year: 2021 Document Type: Article Affiliation country: J.jhin.2021.05.005

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ultraviolet Rays / Coronavirus / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Animals / Humans Language: English Journal: J Hosp Infect Year: 2021 Document Type: Article Affiliation country: J.jhin.2021.05.005