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Hepatic Vasculopathy and Regenerative Responses of the Liver in Fatal Cases of COVID-19.
Kaltschmidt, Barbara; Fitzek, Antonia D E; Schaedler, Julia; Förster, Christine; Kaltschmidt, Christian; Hansen, Torsten; Steinfurth, Fabian; Windmöller, Beatrice A; Pilger, Christian; Kong, Cihang; Singh, Kashika; Nierhaus, Axel; Wichmann, Dominic; Sperhake, Jan; Püschel, Klaus; Huser, Thomas; Krüger, Martin; Robson, Simon C; Wilkens, Ludwig; Schulte Am Esch, Jan.
  • Kaltschmidt B; Department of Cell Biology, Faculty of Biology, University of Bielefeld, Bielefeld, Germany.
  • Fitzek ADE; Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Schaedler J; Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Förster C; Institute of Pathology, KRH Hospital Nordstadt, affiliated with the University Hospital of the University of Bielefeld, Campus Bielefeld-Bethel, Hannover, Germany.
  • Kaltschmidt C; Department of Cell Biology, Faculty of Biology, University of Bielefeld, Bielefeld, Germany.
  • Hansen T; Institute of Pathology, University Hospital OWL of the University of Bielefeld, Campus Klinikum Lippe, Detmold, Germany.
  • Steinfurth F; Department of General and Visceral Surgery, University Hospital OWL of the University of Bielefeld, Campus Bielefeld-Bethel, Bielefeld, Germany.
  • Windmöller BA; Department of Cell Biology, Faculty of Biology, University of Bielefeld, Bielefeld, Germany.
  • Pilger C; Biomolecular Photonics, Faculty of Physics, University of Bielefeld, Bielefeld, Germany.
  • Kong C; Biomolecular Photonics, Faculty of Physics, University of Bielefeld, Bielefeld, Germany.
  • Singh K; Department of General and Visceral Surgery, University Hospital OWL of the University of Bielefeld, Campus Bielefeld-Bethel, Bielefeld, Germany.
  • Nierhaus A; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Wichmann D; Department of Intensive Care Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Sperhake J; Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Püschel K; Department of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Huser T; Biomolecular Photonics, Faculty of Physics, University of Bielefeld, Bielefeld, Germany.
  • Krüger M; Department of Internal Medicine and Gastroenterology, University Hospital OWL of the University of Bielefeld, Campus Bielefeld-Bethel, Bielefeld, Germany.
  • Robson SC; Center for Inflammation Research, Department of Anesthesia and Division of Gastroenterology, Departement of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
  • Wilkens L; Institute of Pathology, KRH Hospital Nordstadt, affiliated with the University Hospital of the University of Bielefeld, Campus Bielefeld-Bethel, Hannover, Germany.
  • Schulte Am Esch J; Department of General and Visceral Surgery, University Hospital OWL of the University of Bielefeld, Campus Bielefeld-Bethel, Bielefeld, Germany. Electronic address: jan.schulteamesch@evkb.de.
Clin Gastroenterol Hepatol ; 19(8): 1726-1729.e3, 2021 08.
Article in English | MEDLINE | ID: covidwho-1317651
ABSTRACT
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects the nasopharynx and lungs and causes coronavirus disease-2019 (COVID-19). It may impact the heart, brain, kidney, and liver.1 Although functional impairment of the liver has been correlated with worse clinical outcomes, little is known about the pathophysiology of hepatic injury and repair in COVID-19.2,3 Histologic evaluation has been limited to small numbers of COVID-19 cases with no control subjects2,4 and demonstrated largely heterogeneous patterns of pathology.2,3.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Gastroenterol Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: J.cgh.2021.01.044

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acute Kidney Injury / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Gastroenterol Hepatol Journal subject: Gastroenterology Year: 2021 Document Type: Article Affiliation country: J.cgh.2021.01.044