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SARS-CoV-2 infection in patients with ß-thalassemia: The French experience.
Jean-Mignard, Estelle; De Luna, Gonzalo; Pascal, Laurent; Agouti, Imane; Thuret, Isabelle.
  • Jean-Mignard E; Département de médecine interne, hôpital de la Timone, Assistance Publique des hôpitaux de Marseille, Marseille, France; Centre de référence des syndromes drépanocytaires majeurs, thalassémies et autres pathologies rares du globule rouge et de l'erythropoïèse, Assistance Publique des hôpitaux de Mar
  • De Luna G; Service de médecine interne, centre de référence des syndromes drépanocytaires majeurs, thalassémies et autres pathologies rares du globule rouge et de l'Erythropoïèse, hôpital Henri Mondor, APHP, Paris, France.
  • Pascal L; Service d'onco-hématologie adulte, hôpital Saint-Vincent de Paul, GH de l'institut catholique de Lille, Lille, France; Centre de référence des syndromes drépanocytaires majeurs, thalassémies et autres pathologies rares du globule rouge et de l'Erythropoïèse, CHRU de Lille, Lille, France.
  • Agouti I; Centre de référence des syndromes drépanocytaires majeurs, thalassémies et autres pathologies rares du globule rouge et de l'erythropoïèse, Assistance Publique des hôpitaux de Marseille, 264, rue Saint-Pierre, 13005 Marseille, France. Electronic address: imane.agouti@ap-hm.fr.
  • Thuret I; Centre de référence des syndromes drépanocytaires majeurs, thalassémies et autres pathologies rares du globule rouge et de l'erythropoïèse, Assistance Publique des hôpitaux de Marseille, 264, rue Saint-Pierre, 13005 Marseille, France.
Transfus Clin Biol ; 29(1): 70-74, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1317783
ABSTRACT

INTRODUCTION:

Because of iron overload complications, thrombosis and infectious predisposition, patients with severe forms of thalassemia are likely to be at increased risk of COVID-19 complications.

RESULTS:

A national survey conducted during the year 2020 across the French reference centers for hemoglobinopathies identified 16 cases of COVID-19 confirmed by RT-PCR in beta-thalassemia patients. Their age ranged from 11 months to 60 years. 15 patients were transfusion-dependent and 6 were splenectomized. Concerning iron overload related complications, none had diabetes or cirrhosis and only one had experienced heart failure. All 4 pediatric patients were pauci-symptomatic during the viral episode. Three patients (41, 49 and 57 years old) developed COVID-19 pneumonia requiring oxygen therapy without the need for mechanical ventilation. Neutropenia (absolute neutrophils count <0.5 10 9/L) was observed in 2 patients receiving long-term treatment with hydroxycarbamide and deferiprone. No thrombosis event, organ failure or death occurred. All patients recovered.

CONCLUSION:

Severity of COVID-19 in this population of young and middle-aged patients appeared increased compared to the general population but remained mild to moderate as already described in the few series reported in the literature. Occurrence of adverse events related to chronic treatment administered in thalassemia disease may be favored by the infectious episode.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thalassemia / Beta-Thalassemia / Iron Overload / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans / Infant / Middle aged Language: English Journal: Transfus Clin Biol Journal subject: Hematology Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thalassemia / Beta-Thalassemia / Iron Overload / COVID-19 Type of study: Observational study / Prognostic study Topics: Long Covid Limits: Child / Humans / Infant / Middle aged Language: English Journal: Transfus Clin Biol Journal subject: Hematology Year: 2022 Document Type: Article