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SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo'.
Dorigatti, Ilaria; Lavezzo, Enrico; Manuto, Laura; Ciavarella, Constanze; Pacenti, Monia; Boldrin, Caterina; Cattai, Margherita; Saluzzo, Francesca; Franchin, Elisa; Del Vecchio, Claudia; Caldart, Federico; Castelli, Gioele; Nicoletti, Michele; Nieddu, Eleonora; Salvadoretti, Elisa; Labella, Beatrice; Fava, Ludovico; Guglielmo, Simone; Fascina, Mariateresa; Grazioli, Marco; Alvisi, Gualtiero; Vanuzzo, Maria Cristina; Zupo, Tiziano; Calandrin, Reginetta; Lisi, Vittoria; Rossi, Lucia; Castagliuolo, Ignazio; Merigliano, Stefano; Unwin, H Juliette T; Plebani, Mario; Padoan, Andrea; Brazzale, Alessandra R; Toppo, Stefano; Ferguson, Neil M; Donnelly, Christl A; Crisanti, Andrea.
  • Dorigatti I; MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK. i.dorigatti@imperial.ac.uk.
  • Lavezzo E; Department of Molecular Medicine, University of Padova, Padova, Italy. enrico.lavezzo@unipd.it.
  • Manuto L; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Ciavarella C; MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK.
  • Pacenti M; Azienda Ospedale Padova, Padova, Italy.
  • Boldrin C; Azienda Ospedale Padova, Padova, Italy.
  • Cattai M; Azienda Ospedale Padova, Padova, Italy.
  • Saluzzo F; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Franchin E; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Del Vecchio C; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Caldart F; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Castelli G; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Nicoletti M; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Nieddu E; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Salvadoretti E; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Labella B; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Fava L; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Guglielmo S; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Fascina M; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Grazioli M; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Alvisi G; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Vanuzzo MC; Azienda Ospedale Padova, Padova, Italy.
  • Zupo T; Azienda Ospedale Padova, Padova, Italy.
  • Calandrin R; Azienda Ospedale Padova, Padova, Italy.
  • Lisi V; Azienda Ospedale Padova, Padova, Italy.
  • Rossi L; Azienda Ospedale Padova, Padova, Italy.
  • Castagliuolo I; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Merigliano S; Department of Surgery, Oncology and Gastroenterology, University of Padova, Padova, Italy.
  • Unwin HJT; MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK.
  • Plebani M; Department of Medicine, University of Padova, Padova, Italy.
  • Padoan A; Department of Medicine, University of Padova, Padova, Italy.
  • Brazzale AR; Department of Statistical Sciences, University of Padova, Padova, Italy.
  • Toppo S; Department of Molecular Medicine, University of Padova, Padova, Italy.
  • Ferguson NM; CRIBI Biotech Centre, University of Padova, Padova, Italy.
  • Donnelly CA; MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK.
  • Crisanti A; MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, London, UK.
Nat Commun ; 12(1): 4383, 2021 07 19.
Article in English | MEDLINE | ID: covidwho-1317806
ABSTRACT
In February and March 2020, two mass swab testing campaigns were conducted in Vo', Italy. In May 2020, we tested 86% of the Vo' population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI) 2.8-4.3%) in May. In November, 98.8% (95% Confidence Interval (CI) 93.7-100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI 11.0-28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI 17.2-36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serologic Tests / COVID-19 Testing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study Limits: Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-24622-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Serologic Tests / COVID-19 Testing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Diagnostic study / Observational study Limits: Female / Humans / Male Country/Region as subject: Europa Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-24622-7