Your browser doesn't support javascript.
Metagenomic identification of a new sarbecovirus from horseshoe bats in Europe.
Crook, Jack M; Murphy, Ivana; Carter, Daniel P; Pullan, Steven T; Carroll, Miles; Vipond, Richard; Cunningham, Andrew A; Bell, Diana.
  • Crook JM; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Murphy I; NIHR Health Protection Unit in Emerging and Zoonotic Infections, Department of Clinical Infection, Microbiology and Immunology, University of Liverpool, Liverpool, L69 7TX, UK.
  • Carter DP; Centre for Ecology, Evolution and Conservation, School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, UK.
  • Pullan ST; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Carroll M; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Vipond R; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
  • Cunningham AA; Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, Oxford University, Oxford, UK.
  • Bell D; National Infection Service, Public Health England, Porton Down, Salisbury, UK.
Sci Rep ; 11(1): 14723, 2021 07 19.
Article in English | MEDLINE | ID: covidwho-1317811
ABSTRACT
The source of the COVID-19 pandemic is unknown, but the natural host of the progenitor sarbecovirus is thought to be Asian horseshoe (rhinolophid) bats. We identified and sequenced a novel sarbecovirus (RhGB01) from a British horseshoe bat, at the western extreme of the rhinolophid range. Our results extend both the geographic and species ranges of sarbecoviruses and suggest their presence throughout the horseshoe bat distribution. Within the spike protein receptor binding domain, but excluding the receptor binding motif, RhGB01 has a 77% (SARS-CoV-2) and 81% (SARS-CoV) amino acid homology. While apparently lacking hACE2 binding ability, and hence unlikely to be zoonotic without mutation, RhGB01 presents opportunity for SARS-CoV-2 and other sarbecovirus homologous recombination. Our findings highlight that the natural distribution of sarbecoviruses and opportunities for recombination through intermediate host co-infection are underestimated. Preventing transmission of SARS-CoV-2 to bats is critical with the current global mass vaccination campaign against this virus.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Betacoronavirus Type of study: Randomized controlled trials Topics: Vaccines Limits: Animals Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-94011-z

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Chiroptera / Betacoronavirus Type of study: Randomized controlled trials Topics: Vaccines Limits: Animals Country/Region as subject: Europa Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-94011-z