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Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro.
Muñoz-Basagoiti, J; Perez-Zsolt, D; León, R; Blanc, V; Raïch-Regué, D; Cano-Sarabia, M; Trinité, B; Pradenas, E; Blanco, J; Gispert, J; Clotet, B; Izquierdo-Useros, N.
  • Muñoz-Basagoiti J; IrsiCaixa AIDS Research Institute, Badalona, Spain.
  • Perez-Zsolt D; IrsiCaixa AIDS Research Institute, Badalona, Spain.
  • León R; Dentaid Research Center, Cerdanyola del Vallès, Spain.
  • Blanc V; Dentaid Research Center, Cerdanyola del Vallès, Spain.
  • Raïch-Regué D; IrsiCaixa AIDS Research Institute, Badalona, Spain.
  • Cano-Sarabia M; Catalan Institute of Nanoscience and Nanotechnology, CSIC, and the Barcelona Institute of Science and Technology, Bellaterra (Barcelona), Spain.
  • Trinité B; IrsiCaixa AIDS Research Institute, Badalona, Spain.
  • Pradenas E; IrsiCaixa AIDS Research Institute, Badalona, Spain.
  • Blanco J; IrsiCaixa AIDS Research Institute, Badalona, Spain.
  • Gispert J; Germans Trias i Pujol Research Institute, Can Ruti Campus, Badalona, Spain.
  • Clotet B; University of Vic-Central University of Catalonia, Vic, Spain.
  • Izquierdo-Useros N; Dentaid Research Center, Cerdanyola del Vallès, Spain.
J Dent Res ; 100(11): 1265-1272, 2021 10.
Article in English | MEDLINE | ID: covidwho-1318252
ABSTRACT
Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity in these oral rinses and their exact mechanism of action remain unknown. Here we show that cetylpyridinium chloride (CPC), a quaternary ammonium compound in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting the viral fusion step with target cells after disrupting the integrity of the viral envelope. We also found that CPC-containing mouth rinses decreased more than a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. This activity was effective for different SARS-CoV-2 variants, including the B.1.1.7 or Alpha variant originally identified in United Kingdom, and in the presence of sterilized saliva. CPC-containing mouth rinses could therefore represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals regardless of the variants they are infected with.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mouthwashes Topics: Variants Limits: Humans Language: English Journal: J Dent Res Year: 2021 Document Type: Article Affiliation country: 00220345211029269

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mouthwashes Topics: Variants Limits: Humans Language: English Journal: J Dent Res Year: 2021 Document Type: Article Affiliation country: 00220345211029269