Mouthwashes with CPC Reduce the Infectivity of SARS-CoV-2 Variants In Vitro.
J Dent Res
; 100(11): 1265-1272, 2021 10.
Article
in English
| MEDLINE | ID: covidwho-1318252
ABSTRACT
Oral mouthwashes decrease the infectivity of several respiratory viruses including SARS-CoV-2. However, the precise agents with antiviral activity in these oral rinses and their exact mechanism of action remain unknown. Here we show that cetylpyridinium chloride (CPC), a quaternary ammonium compound in many oral mouthwashes, reduces SARS-CoV-2 infectivity by inhibiting the viral fusion step with target cells after disrupting the integrity of the viral envelope. We also found that CPC-containing mouth rinses decreased more than a thousand times the infectivity of SARS-CoV-2 in vitro, while the corresponding vehicles had no effect. This activity was effective for different SARS-CoV-2 variants, including the B.1.1.7 or Alpha variant originally identified in United Kingdom, and in the presence of sterilized saliva. CPC-containing mouth rinses could therefore represent a cost-effective measure to reduce SARS-CoV-2 infectivity in saliva, aiding to reduce viral transmission from infected individuals regardless of the variants they are infected with.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
COVID-19
/
Mouthwashes
Topics:
Variants
Limits:
Humans
Language:
English
Journal:
J Dent Res
Year:
2021
Document Type:
Article
Affiliation country:
00220345211029269
Similar
MEDLINE
...
LILACS
LIS