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Post-infection cognitive impairments in a cohort of elderly patients with COVID-19.
Liu, Yu-Hui; Wang, Ye-Ran; Wang, Qing-Hua; Chen, Yang; Chen, Xian; Li, Ying; Cen, Yuan; Xu, Cheng; Hu, Tian; Liu, Xu-Dong; Yang, Ling-Li; Li, Si-Jing; Liu, Xue-Fei; Liu, Chun-Mei; Zhu, Jie; Li, Wei; Zhang, Li-Li; Liu, Juan; Wang, Yan-Jiang.
  • Liu YH; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Wang YR; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Wang QH; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Chen Y; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Chen X; Department of Anaesthesiology, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Li Y; Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Cen Y; Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Xu C; Department of Oncology, General Hospital of the Central Theatre Command of the People's Liberation Army, Wuhan, China.
  • Hu T; Department of Anaesthesiology, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Liu XD; Department of Anaesthesiology, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Yang LL; Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Li SJ; Department of Orthopedics, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Liu XF; Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Liu CM; Department of Ophthalmology, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Zhu J; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Li W; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Zhang LL; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China.
  • Liu J; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. liujuan961@163.com.
  • Wang YJ; Department of Neurology and Centre for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, China. yanjiang_wang@tmmu.edu.cn.
Mol Neurodegener ; 16(1): 48, 2021 07 19.
Article in English | MEDLINE | ID: covidwho-1318288
ABSTRACT

BACKGROUND:

Understanding the long-term effects of coronavirus disease 2019 (COVID-19) on cognitive function is essential for monitoring the cognitive decline in the elderly population. This study aims to assess the current cognitive status and the longitudinal cognitive decline in elderly patients recovered from COVID-19.

METHODS:

This cross-sectional study recruited 1539 COVID-19 inpatients aged over 60 years who were discharged from three COVID-19-designated hospitals in Wuhan, China, from February 10 to April 10, 2020. In total, 466 uninfected spouses of COVID-19 patients were selected as controls. The current cognitive status was assessed using a Chinese version of the Telephone Interview of Cognitive Status-40 (TICS-40) and the longitudinal cognitive decline was assessed using an Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE). Cognitive assessments were performed 6 months after patient discharge.

RESULTS:

Compared with controls, COVID-19 patients had lower TICS-40 scores and higher IQCODE scores [TICS-40 median (IQR) 29 (25 to 32) vs. 30 (26 to 33), p < 0.001; IQCODE median (IQR) 3.19 (3.00 to 3.63) vs. 3.06 (3.00 to 3.38), p < 0.001]. Severe COVID-19 patients had lower TICS-40 scores and higher IQCODE scores than non-severe COVID-19 patients [TICS-40 median (IQR) 24 (18 to 28) vs. 30 (26 to 33), p < 0.001; IQCODE median (IQR) 3.63 (3.13 to 4.31) vs. 3.13 (3.00 to 3.56), p < 0.001] and controls [TICS-40 median (IQR) 24 (18 to 28) vs. 30 (26 to 33), p < 0.001; IQCODE median (IQR) 3.63 (3.13 to 4.31) vs. 3.06 (3.00 to 3.38), p < 0.001]. Severe COVID-19 patients had a higher proportion of cases with current cognitive impairment and longitudinal cognitive decline than non-severe COVID-19 patients [dementia 25 (10.50 %) vs. 9 (0.69 %), p < 0.001; Mild cognitive impairment (MCI) 60 (25.21 %) vs. 63 (4.84 %), p < 0.001] and controls [dementia 25 (10.50 %) vs. 0 (0 %), p < 0.001; MCI 60 (25.21 %) vs. 20 (4.29 %), p < 0.001)]. COVID-19 severity, delirium and COPD were risk factors of current cognitive impairment. Low education level, severe COVID-19, delirium, hypertension and COPD were risk factors of longitudinal cognitive decline.

CONCLUSIONS:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with an increased risk of long-term cognitive decline in elderly population. COVID-19 patients, especially severe patients, should be intensively monitored for post-infection cognitive decline.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognitive Dysfunction / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Mol Neurodegener Year: 2021 Document Type: Article Affiliation country: S13024-021-00469-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cognitive Dysfunction / COVID-19 Type of study: Cohort study / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Mol Neurodegener Year: 2021 Document Type: Article Affiliation country: S13024-021-00469-w