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Repurposing colchicine's journey in view of drug-to-drug interactions. A review.
Vrachatis, Dimitrios A; Papathanasiou, Konstantinos A; Giotaki, Sotiria G; Iliodromitis, Konstantinos E; Papaioannou, Theodore G; Stefanini, Giulio G; Cleman, Michael; Siasos, Gerasimos; Reimers, Bernhard; Lansky, Alexandra; Tardif, Jean-Claude; Deftereos, Spyridon G; Giannopoulos, George.
  • Vrachatis DA; 2nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece.
  • Papathanasiou KA; 2nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece.
  • Giotaki SG; 2nd Department of Cardiology, National and Kapodistrian University of Athens, Athens, Greece.
  • Iliodromitis KE; Evangelisches Krankenhaus Hagen-Haspe, Clinic for Cardiology and Electrophysiology, Germany.
  • Papaioannou TG; First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Greece.
  • Stefanini GG; Department of History of Medicine and Medical Ethics, Medical School, National and Kapodistrian University of Athens, Greece.
  • Cleman M; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Siasos G; Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy.
  • Reimers B; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
  • Lansky A; 3rd Department of Cardiology, "Sotiria Hospital", National and Kapodistrian University of Athens, Athens, Greece.
  • Tardif JC; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
  • Deftereos SG; Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy.
  • Giannopoulos G; Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Toxicol Rep ; 8: 1389-1393, 2021.
Article in English | MEDLINE | ID: covidwho-1318618
ABSTRACT
Colchicine's medical evolution is historically bound to the Mediterranean basin, since remarkable researchers from this region underscored its valuable properties. With the passing of years colchicine became an essential pharmaceutical substance for the treatment of rheumatologic and cardiovascular diseases. In light of recent findings, the therapeutic value of colchicine has grown. In clinical practice, colchicine remains underutilized in view of its proven efficacy and safety. Its complex pharmacokinetics and multifaceted anti-inflammatory role remain under investigation. The current review addresses the safe administration of colchicine in view of key drug to drug interactions. Finally, we are briefly presenting colchicine's future potential applications.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Toxicol Rep Year: 2021 Document Type: Article Affiliation country: J.toxrep.2021.07.009

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: Toxicol Rep Year: 2021 Document Type: Article Affiliation country: J.toxrep.2021.07.009