SARS-CoV-2 and pathological matrix remodeling mediators.
Inflamm Res
; 70(8): 847-858, 2021 Aug.
Article
in English
| MEDLINE | ID: covidwho-1318745
ABSTRACT
BACKGROUND:
Recognizing only sharp elevation in a short period of time, the COVID-19 SARS-CoV-2 propagation is more and more marked in the whole world. Induced inflammation afterwards infection engenders a high infiltration of immune cells and cytokines that triggers matrix metalloproteinases (MMPs) activation. These endopeptidases are mediators of the lung extracellular matrix (ECM), a basic element for alveoli structure and gas exchange.METHODS:
When immune cells, MMPs, secreted cytokines and several other mediators are gathered a pathological matrix remodeling occurs. This phenomenon tends to tissue destruction in the first place and a pulmonary hypertrophy and fibrosis in the second place.FINDINGS:
After pathological matrix remodeling establishment, pathological diseases take place even after infection state. Since post COVID-19 pulmonary fibrosis is an emerging complication of the disease, there is an urge to better understand and characterize the implication of ECM remodeling during SARS-CoV-2 infection.CONCLUSION:
Targeting MMPs and their inhibitors could be a probable solution for occurred events since there are many cured patients that remain with severe sequels even after the end of infection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Matrix Metalloproteinases
/
Extracellular Matrix
/
SARS-CoV-2
/
COVID-19
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Inflamm Res
Journal subject:
Allergy and Immunology
/
Pathology
Year:
2021
Document Type:
Article
Affiliation country:
S00011-021-01487-6
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