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Association between early treatment with Qingfei Paidu decoction and favorable clinical outcomes in patients with COVID-19: A retrospective multicenter cohort study.
Shi, Nannan; Liu, Bin; Liang, Ning; Ma, Yan; Ge, Youwen; Yi, Honggang; Wo, Hongmei; Gu, Heng; Kuang, Yuan; Tang, Shaowen; Zhao, Yang; Tong, Lin; Liu, Sihong; Zhao, Chen; Chen, Renbo; Bai, Weiguo; Fan, Yipin; Shi, Zhan; Li, Li; Liu, Jia; Gu, Hao; Zhi, Yingjie; Wang, Zhifei; Li, Yuanyuan; Li, Huizhen; Wang, Jingya; Jiao, Liwen; Tian, Yaxin; Xiong, Yibai; Huo, Ruili; Zhang, Xiaohui; Bai, Jiangfeng; Chen, Hong; Chen, Liying; Feng, Qiao; Guo, Tuanmao; Hou, Yong; Hu, Guifen; Hu, Xiaomei; Hu, Yunhong; Huang, Jin; Huang, Qiuhua; Huang, Shaozhen; Ji, Liang; Jin, Haihao; Lei, Xiao; Li, Chunyan; Wu, Guihui; Li, Jike; Li, Minqing.
  • Shi N; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Liu B; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Liang N; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Ma Y; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Ge Y; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Yi H; School of Public Health, Nanjing Medical University, Nanjing, China.
  • Wo H; School of Health Policy and Management, Nanjing Medical University, Nanjing, China.
  • Gu H; School of Public Health, Nanjing Medical University, Nanjing, China.
  • Kuang Y; School of Public Health, Nanjing Medical University, Nanjing, China.
  • Tang S; School of Public Health, Nanjing Medical University, Nanjing, China.
  • Zhao Y; School of Public Health, Nanjing Medical University, Nanjing, China.
  • Tong L; Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Liu S; Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Zhao C; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Chen R; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Bai W; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Fan Y; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Shi Z; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Li L; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Liu J; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Gu H; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Zhi Y; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Wang Z; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Li Y; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Li H; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Wang J; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Jiao L; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Tian Y; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Xiong Y; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
  • Huo R; China Academy of Chinese Medical Sciences, Beijing, China.
  • Zhang X; Institute of Medical Information, Chinese Academy of Medical Science, Beijing, China.
  • Bai J; Department of Infectious Disease, Yulin Chinese Medicine Hospital, Shaanxi, China.
  • Chen H; President's Office, The First Hospital of Qiqiha, Heilongjiang, China.
  • Chen L; Department of Traditional Chinese Medicine, Shangluo Central Hospital, Shaanxi, China.
  • Feng Q; Department of Traditional Chinese Medicine, The People's Hospital of QiTaiHe, Heilongjiang, China.
  • Guo T; Department of Scientific Research, Xianyang Central Hospital, Shaanxi, China.
  • Hou Y; The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Anhui, China.
  • Hu G; Department of Infectious Disease, HePing Hospital Affiliated to ChangZhi Medical College, Shanxi, China.
  • Hu X; Department of Traditional Chinese Medicine, Langfang Hospital of Chinese Medicine, Hebei, China.
  • Hu Y; Department of Traditional Chinese Medicine, Xingtai Hospital of Chinese Medicine, Hebei, China.
  • Huang J; Department of Traditional Chinese Medicine, The People's Hospital of GuangXi Zhuang Autonomous Region, Guangxi, China.
  • Huang Q; Department of Traditional Chinese Medicine, The People's Hospital of GuangXi Zhuang Autonomous Region, Guangxi, China.
  • Huang S; Department of Traditional Chinese Medicine, The First People's Hospital of Fangchenggang, Guangxi, China.
  • Ji L; Department of Traditional Chinese Medicine, Mianyang Hospital of Traditional Chinese Medicine, Sichuan, China.
  • Jin H; Department of Traditional Chinese Medicine, Liuzhou People's Hospital, Guangxi, China.
  • Lei X; Department of Traditional Chinese Medicine, Affiliated Hospital of North Sichuan Medical College, Sichuan, China.
  • Li C; Department of Infectious Disease, Yan'an Second People's Hospital, Shaanxi, China.
  • Wu G; Department of Traditional Chinese Medicine, The Public Health Clinical Center of Chengdu, Sichuan, China.
  • Li J; Department of Traditional Chinese Medicine, The Public Health Clinical Center of Chengdu, Sichuan, China.
  • Li M; Department of Traditional Chinese Medicine, Dazhou Central Hospital, Sichuan, China.
Pharmacol Res ; 161: 105290, 2020 11.
Article in English | MEDLINE | ID: covidwho-1318948
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Favorable Clinical Outcome PROCESS_OF Patients
Subject
Favorable Clinical Outcome
Predicate
PROCESS_OF
Object
Patients
3. qingfei paidu decoction TREATS Symptoms
Subject
qingfei paidu decoction
Predicate
TREATS
Object
Symptoms
4. qingfei paidu decoction TREATS Fasting
Subject
qingfei paidu decoction
Predicate
TREATS
Object
Fasting
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Favorable Clinical Outcome PROCESS_OF Patients
Subject
Favorable Clinical Outcome
Predicate
PROCESS_OF
Object
Patients
7. qingfei paidu decoction TREATS Symptoms
Subject
qingfei paidu decoction
Predicate
TREATS
Object
Symptoms
8. qingfei paidu decoction TREATS Fasting
Subject
qingfei paidu decoction
Predicate
TREATS
Object
Fasting
ABSTRACT
The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between early treatment with Qingfei Paidu decoction (QFPDD) and favorable clinical outcomes. In this retrospective multicenter study, we included 782 patients (males, 56 %; median age 46) with confirmed COVID-19 from 54 hospitals in nine provinces of China, who were divided into four groups according to the treatment initiation time from the first date of onset of symptoms to the date of starting treatment with QFPDD. The primary outcome was time to recovery; days of viral shedding, duration of hospital stay, and course of the disease were also analyzed. Compared with treatment initiated after 3 weeks, early treatment with QFPDD after less than 1 week, 1-2 weeks, or 2-3 weeks had a higher likelihood of recovery, with adjusted hazard ratio (HR) (95 % confidence interval [CI]) of 3.81 (2.65-5.48), 2.63 (1.86-3.73), and 1.92 (1.34-2.75), respectively. The median course of the disease decreased from 34 days to 24 days, 21 days, and 18 days when treatment was administered early by a week (P < 0.0001). Treatment within a week was related to a decrease by 1-4 days in the median duration of hospital stay compared with late treatment (P<0.0001). In conclusion, early treatment with QFPDD may serve as an effective strategy in controlling the epidemic, as early treatment with QFPDD was associated with favorable outcomes, including faster recovery, shorter time to viral shedding, and a shorter duration of hospital stay. However, further multicenter, prospective studies with a larger sample size should be conducted to confirm the benefits of early treatment with QFPDD.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Randomized controlled trials / Risk factors / Screening study Topics: Long Covid / Traditional medicine Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Pharmacol Res Journal subject: Pharmacology Year: 2020 Document Type: Article Affiliation country: J.phrs.2020.105290

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drugs, Chinese Herbal / COVID-19 Type of study: Etiology study / Incidence study / Observational study / Prognostic study / Randomized controlled trials / Risk factors / Screening study Topics: Long Covid / Traditional medicine Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Asia Language: English Journal: Pharmacol Res Journal subject: Pharmacology Year: 2020 Document Type: Article Affiliation country: J.phrs.2020.105290