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Airway and Alveoli Organoids as Valuable Research Tools in COVID-19.
de Oliveira, Miriane; De Sibio, Maria T; Costa, Felipe A S; Sakalem, Marna E.
  • de Oliveira M; Department of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), District of Rubião Jr, s/n, 18618-000, Botucatu, São Paulo, Brazil.
  • De Sibio MT; Department of Internal Clinic, Botucatu Medicine School, São Paulo State University (UNESP), District of Rubião Jr, s/n, 18618-000, Botucatu, São Paulo, Brazil.
  • Costa FAS; São Paulo State University (UNESP), School of Agricultural Sciences, Department of Bioprocesses and Biotechnology, Central Multiuser Laboratory, Av. Universitária, no 3780, Altos do Paraíso, 18610-034, Botucatu, Sao Paulo, Brazil.
  • Sakalem ME; Department of Anatomy, CCB, State University of Londrina (UEL), Campus Universitário s/n, Caixa Postal 10011, 86057-970, Londrina, Parana, Brazil.
ACS Biomater Sci Eng ; 7(8): 3487-3502, 2021 08 09.
Article in English | MEDLINE | ID: covidwho-1319013
ABSTRACT
The coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, SARS-CoV-2, affects tissues from different body systems but mostly the respiratory system, and the damage evoked in the lungs may occasionally result in severe respiratory complications and eventually lead to death. Studies of human respiratory infections have been limited by the scarcity of functional models that mimic in vivo physiology and pathophysiology. In the last decades, organoid models have emerged as potential research tools due to the possibility of reproducing in vivo tissue in culture. Despite being studied for over one year, there is still no effective treatment against COVID-19, and investigations using pulmonary tissue and possible therapeutics are still very limited. Thus, human lung organoids can provide robust support to simulate SARS-CoV-2 infection and replication and aid in a better understanding of their effects in human tissue. The present review describes methodological aspects of different protocols to develop airway and alveoli organoids, which have a promising perspective to further investigate COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organoids / COVID-19 Limits: Humans Language: English Journal: ACS Biomater Sci Eng Year: 2021 Document Type: Article Affiliation country: Acsbiomaterials.1c00306

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Organoids / COVID-19 Limits: Humans Language: English Journal: ACS Biomater Sci Eng Year: 2021 Document Type: Article Affiliation country: Acsbiomaterials.1c00306