SARS-CoV-2 Human Challenge Studies - Establishing the Model during an Evolving Pandemic.

Rapeport, Garth; Smith, Emma; Gilbert, Anthony; Catchpole, Andrew; McShane, Helen; Chiu, Christopher

Rapeport, Garth; Smith, Emma; Gilbert, Anthony; Catchpole, Andrew; McShane, Helen; Chiu, Christopher.

Rapeport G; From the National Heart and Lung Institute (G.R., E.S.) and the Department of Infectious Disease (C.C.), Imperial College London; the U.K. Vaccines Taskforce (A.G.); and hVIVO Services (A.C.) - all in London; and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom (H.M.).
Smith E; From the National Heart and Lung Institute (G.R., E.S.) and the Department of Infectious Disease (C.C.), Imperial College London; the U.K. Vaccines Taskforce (A.G.); and hVIVO Services (A.C.) - all in London; and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom (H.M.).
Gilbert A; From the National Heart and Lung Institute (G.R., E.S.) and the Department of Infectious Disease (C.C.), Imperial College London; the U.K. Vaccines Taskforce (A.G.); and hVIVO Services (A.C.) - all in London; and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom (H.M.).
Catchpole A; From the National Heart and Lung Institute (G.R., E.S.) and the Department of Infectious Disease (C.C.), Imperial College London; the U.K. Vaccines Taskforce (A.G.); and hVIVO Services (A.C.) - all in London; and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom (H.M.).
McShane H; From the National Heart and Lung Institute (G.R., E.S.) and the Department of Infectious Disease (C.C.), Imperial College London; the U.K. Vaccines Taskforce (A.G.); and hVIVO Services (A.C.) - all in London; and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom (H.M.).
Chiu C; From the National Heart and Lung Institute (G.R., E.S.) and the Department of Infectious Disease (C.C.), Imperial College London; the U.K. Vaccines Taskforce (A.G.); and hVIVO Services (A.C.) - all in London; and the Department of Paediatrics, University of Oxford, Oxford, United Kingdom (H.M.).

N Engl J Med ; 385(11): 961-964, 2021 Sep 09.

Article in English | MEDLINE | ID: covidwho-1319063

Subject(s)

Antiviral Agents/therapeutic use; COVID-19 Vaccines; COVID-19; Clinical Trials as Topic/organization & administration; Human Experimentation/standards; SARS-CoV-2; COVID-19/immunology; COVID-19/prevention & control; COVID-19/therapy; Clinical Trials as Topic/ethics; Humans

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Clinical Trials as Topic / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 / Human Experimentation Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: N Engl J Med Year: 2021 Document Type: Article

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