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Comparison of electrocardiograms (ECG) waveforms and centralized ECG measurements between a simple 6-lead mobile ECG device and a standard 12-lead ECG.
Kleiman, Robert; Darpo, Borje; Brown, Randy; Rudo, Todd; Chamoun, Svetlana; Albert, David E; Bos, Johan Martijn; Ackerman, Michael J.
  • Kleiman R; eResearch Technology Inc, Philadelphia, PA, USA.
  • Darpo B; eResearch Technology Inc, Philadelphia, PA, USA.
  • Brown R; PPD Inc, Wilmington, NC, USA.
  • Rudo T; eResearch Technology Inc, Philadelphia, PA, USA.
  • Chamoun S; eResearch Technology Inc, Philadelphia, PA, USA.
  • Albert DE; AliveCor Corporation, San Francisco, CA, USA.
  • Bos JM; Windland Smith Rice Comprehensive Sudden Cardiac Death Program, Divisions of Heart Rhythm Services and Pediatric Cardiology, Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
  • Ackerman MJ; Windland Smith Rice Comprehensive Sudden Cardiac Death Program, Divisions of Heart Rhythm Services and Pediatric Cardiology, Departments of Cardiovascular Medicine, Pediatric and Adolescent Medicine, and Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
Ann Noninvasive Electrocardiol ; 26(6): e12872, 2021 11.
Article in English | MEDLINE | ID: covidwho-1319236
ABSTRACT

BACKGROUND:

Interval duration measurements (IDMs) were compared between standard 12-lead electrocardiograms (ECGs) and 6-lead ECGs recorded with AliveCor's KardiaMobile 6L, a hand-held mobile device designed for use by patients at home.

METHODS:

Electrocardiograms were recorded within, on average, 15 min from 705 patients in Mayo Clinic's Windland Smith Rice Genetic Heart Rhythm Clinic. Interpretable 12-lead and 6-lead recordings were available for 685 out of 705 (97%) eligible patients. The most common diagnosis was congenital long QT syndrome (LQTS, 343/685 [50%]), followed by unaffected relatives and patients (146/685 [21%]), and patients with other genetic heart diseases, including hypertrophic cardiomyopathy (36 [5.2%]), arrhythmogenic cardiomyopathy (23 [3.4%]), and idiopathic ventricular fibrillation (14 [2.0%]). IDMs were performed by a central ECG laboratory using lead II with a semi-automated technique.

RESULTS:

Despite differences in patient position (supine for 12-lead ECGs and sitting for 6-lead ECGs), mean IDMs were comparable, with mean values for the 12-lead and 6-lead ECGs for QTcF, heart rate, PR, and QRS differing by 2.6 ms, -5.5 beats per minute, 1.0 and 1.2 ms, respectively. Despite a modest difference in heart rate, intervals were close enough to allow a detection of clinically meaningful abnormalities.

CONCLUSIONS:

The 6-lead hand-held device is potentially useful for a clinical follow-up of remote patients, and for a safety follow-up of patients participating in clinical trials who cannot visit the investigational site. This technology may extend the use of 12-lead ECG recordings during the current COVID-19 pandemic as remote patient monitoring becomes more common in virtual or hybrid-design clinical studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Electrocardiography / Heart Diseases Type of study: Observational study Topics: Long Covid Limits: Adult / Female / Humans / Male Language: English Journal: Ann Noninvasive Electrocardiol Journal subject: Cardiology Year: 2021 Document Type: Article Affiliation country: Anec.12872

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Electrocardiography / Heart Diseases Type of study: Observational study Topics: Long Covid Limits: Adult / Female / Humans / Male Language: English Journal: Ann Noninvasive Electrocardiol Journal subject: Cardiology Year: 2021 Document Type: Article Affiliation country: Anec.12872