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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection.
Pérez-Gómez, Alberto; Vitallé, Joana; Gasca-Capote, Carmen; Gutierrez-Valencia, Alicia; Trujillo-Rodriguez, María; Serna-Gallego, Ana; Muñoz-Muela, Esperanza; Jiménez-Leon, María de Los Reyes; Rafii-El-Idrissi Benhnia, Mohamed; Rivas-Jeremias, Inmaculada; Sotomayor, Cesar; Roca-Oporto, Cristina; Espinosa, Nuria; Infante-Domínguez, Carmen; Crespo-Rivas, Juan Carlos; Fernández-Villar, Alberto; Pérez-González, Alexandre; López-Cortés, Luis Fernando; Poveda, Eva; Ruiz-Mateos, Ezequiel.
  • Pérez-Gómez A; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Vitallé J; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Gasca-Capote C; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Gutierrez-Valencia A; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Trujillo-Rodriguez M; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Serna-Gallego A; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Muñoz-Muela E; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Jiménez-Leon MLR; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Rafii-El-Idrissi Benhnia M; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Rivas-Jeremias I; Department of Medical Biochemistry, Molecular Biology, and Immunology, School of Medicine, University of Seville, Seville, Spain.
  • Sotomayor C; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Roca-Oporto C; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Espinosa N; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Infante-Domínguez C; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Crespo-Rivas JC; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Fernández-Villar A; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
  • Pérez-González A; Pneumology Service, Galicia Sur Health Research Instituto (IIS Galicia Sur), SERGAS-UVigo, Vigo, Spain.
  • López-Cortés LF; Infectious Diseases Unit, Department of Internal Medicine, Complexo HospitalarioUniversitario de Vigo, IIS Galicia Sur, SERGAS-UVigo, Vigo, Spain.
  • Poveda E; Group of Virology and Pathogenesis, Galicia Sur Health Research Institute (IIS Galicia Sur)-Complexo Hospitalario Universitario de Vigo, SERGAS-UVigo, Vigo, Spain.
  • Ruiz-Mateos E; Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine, Institute of Biomedicine of Seville (IBiS), Virgen del Rocío University Hospital, CSIC, University of Seville, Seville, Spain.
Cell Mol Immunol ; 18(9): 2128-2139, 2021 09.
Article in English | MEDLINE | ID: covidwho-1320227
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin ß7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Cell Mol Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41423-021-00728-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dendritic Cells / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Topics: Long Covid Limits: Female / Humans / Male Language: English Journal: Cell Mol Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41423-021-00728-2