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Impact of repeated nasal sampling on detection and quantification of SARS-CoV-2.
Levy, Joshua M; Frediani, Jennifer K; Tyburski, Erika A; Wood, Anna; Figueroa, Janet; Kempker, Russell R; Rebolledo, Paulina A; Gonzalez, Mark D; Sullivan, Julie; Vos, Miriam B; O'Neal, Jared; Martin, Greg S; Lam, Wilbur A; Waggoner, Jesse J.
  • Levy JM; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
  • Frediani JK; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.
  • Tyburski EA; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, GA, USA.
  • Wood A; Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
  • Figueroa J; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
  • Kempker RR; Georgia Institute of Technology, Atlanta, GA, USA.
  • Rebolledo PA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Gonzalez MD; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
  • Sullivan J; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
  • Vos MB; Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
  • O'Neal J; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
  • Martin GS; Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
  • Lam WA; Rollins School of Public Health, Emory University, Atlanta, GA, USA.
  • Waggoner JJ; The Atlanta Center for Microsystems-Engineered Point-of-Care Technologies, Atlanta, GA, USA.
Sci Rep ; 11(1): 14903, 2021 07 21.
Article in English | MEDLINE | ID: covidwho-1320242
ABSTRACT
The impact of repeated sample collection on COVID-19 test performance is unknown. The FDA and CDC currently recommend the primary collection of diagnostic samples to minimize the perceived risk of false-negative findings. We therefore evaluated the association between repeated sample collection and test performance among 325 symptomatic patients undergoing COVID-19 testing in Atlanta, GA. High concordance was found between consecutively collected mid-turbinate samples with both molecular (n = 74, 100% concordance) and antigen-based (n = 147, 97% concordance, kappa = 0.95, CI = 0.88-1.00) diagnostic assays. Repeated sample collection does not decrease COVID-19 test performance, demonstrating that multiple samples can be collected for assay validation and clinical diagnosis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Specimen Handling / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-94547-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Specimen Handling / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-94547-0