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Monoclonal Antibodies for Early Treatment of COVID-19 in a World of Evolving SARS-CoV-2 Mutations and Variants.
Pogue, Jason M; Lauring, Adam S; Gandhi, Tejal N; Marshall, Vincent D; Eschenauer, Gregory A; Nagel, Jerod L; Baang, Ji Hoon; Zhou, Shiwei; Valesano, Andrew L; Petty, Lindsay A.
  • Pogue JM; University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
  • Lauring AS; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Gandhi TN; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Marshall VD; University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
  • Eschenauer GA; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
  • Nagel JL; University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.
  • Baang JH; Department of Pharmacy, Michigan Medicine, Ann Arbor, Michigan, USA.
  • Zhou S; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Valesano AL; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
  • Petty LA; University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Open Forum Infect Dis ; 8(7): ofab268, 2021 Jul.
Article in English | MEDLINE | ID: covidwho-1320320
ABSTRACT
Monoclonal antibodies targeting the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 spike protein are important outpatient treatment options in coronavirus disease 2019 to mitigate progression of disease and prevent hospitalization. The impact of different RBD mutations on the efficacy of the available monoclonal antibodies and processes for incorporating this impact into treatment algorithms are ill defined. Herein, we synthesize the data surrounding the impact of key RBD mutations on the efficacy of US Food and Drug Administration Emergency Use Authorized monoclonal antibodies and describe our approach at Michigan Medicine at monitoring mutation frequency in circulating virus and developing an algorithm that incorporates these data into outpatient treatment pathways.
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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Topics: Variants Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid