Changes in the presentation of newly diagnosed type 1 diabetes in children during the COVID-19 pandemic in a tertiary center in Southern Turkey.
J Pediatr Endocrinol Metab
; 34(10): 1303-1309, 2021 Oct 26.
Article
in English
| MEDLINE | ID: covidwho-1320552
ABSTRACT
OBJECTIVES:
The COVID-19 pandemic is a global health problem with high morbidity and mortality. This study aimed to investigate patients who were diagnosed with type 1 diabetes during the pandemic and evaluate the effect of the pandemic on the clinical findings of these patients by comparing them with findings from a year prior.METHODS:
Patients diagnosed with type 1 diabetes mellitus between 2019 and 2021 were separated into two groups Patients diagnosed prepandemic and those diagnosed during the pandemic.RESULTS:
The number of newly diagnosed diabetes cases increased from 46 in the prepandemic period to 74 in the pandemic period. The number of cases diagnosed with diabetic ketoacidosis (DKA) in the clinic increased from 58.7 to 91.9%. We found that moderate and severe DKA rates from 18.5 and 14.8% to 23.5 and 22.1%, respectively. Besides, the average HbA1c was higher, while the average bicarbonate was lower in cases diagnosed during the pandemic period compared to the prepandemic period (p=0.048 and p<0.001, respectively). We found that celiac autoantibody positivity antibodies to glutamic acid decarboxylase (anti GAD) positivity, and islet cell antibodies (ICA), ICA and anti GAD positivity coexistence were higher (p=0.045, p=0.008, and p=0.007, respectively) among the patients diagnosed during the pandemic.CONCLUSIONS:
We observed an increase in the number of patients newly diagnosed with type 1 diabetes mellitus, an increase in autoantibody positivity, and higher rates and severity of DKA during the COVID-19 pandemic period compared to the prepandemic period.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Diabetes Mellitus, Type 1
/
SARS-CoV-2
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adolescent
/
Child
/
Child, preschool
/
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
J Pediatr Endocrinol Metab
Journal subject:
Endocrinology
/
Pediatrics
Year:
2021
Document Type:
Article
Affiliation country:
Jpem-2021-0287
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