Your browser doesn't support javascript.
Changes in the presentation of newly diagnosed type 1 diabetes in children during the COVID-19 pandemic in a tertiary center in Southern Turkey.
Dilek, Semine Özdemir; Gürbüz, Fatih; Turan, Ihsan; Celiloglu, Can; Yüksel, Bilgin.
  • Dilek SÖ; Division of Pediatric Endocrinology, Cukurova University Faculty of Medicine, Adana, Turkey.
  • Gürbüz F; Division of Pediatric Endocrinology, Cukurova University Faculty of Medicine, Adana, Turkey.
  • Turan I; Division of Pediatric Endocrinology, Cukurova University Faculty of Medicine, Adana, Turkey.
  • Celiloglu C; Division of Pediatric Endocrinology, Cukurova University Faculty of Medicine, Adana, Turkey.
  • Yüksel B; Division of Pediatric Endocrinology, Cukurova University Faculty of Medicine, Adana, Turkey.
J Pediatr Endocrinol Metab ; 34(10): 1303-1309, 2021 Oct 26.
Article in English | MEDLINE | ID: covidwho-1320552
ABSTRACT

OBJECTIVES:

The COVID-19 pandemic is a global health problem with high morbidity and mortality. This study aimed to investigate patients who were diagnosed with type 1 diabetes during the pandemic and evaluate the effect of the pandemic on the clinical findings of these patients by comparing them with findings from a year prior.

METHODS:

Patients diagnosed with type 1 diabetes mellitus between 2019 and 2021 were separated into two groups Patients diagnosed prepandemic and those diagnosed during the pandemic.

RESULTS:

The number of newly diagnosed diabetes cases increased from 46 in the prepandemic period to 74 in the pandemic period. The number of cases diagnosed with diabetic ketoacidosis (DKA) in the clinic increased from 58.7 to 91.9%. We found that moderate and severe DKA rates from 18.5 and 14.8% to 23.5 and 22.1%, respectively. Besides, the average HbA1c was higher, while the average bicarbonate was lower in cases diagnosed during the pandemic period compared to the prepandemic period (p=0.048 and p<0.001, respectively). We found that celiac autoantibody positivity antibodies to glutamic acid decarboxylase (anti GAD) positivity, and islet cell antibodies (ICA), ICA and anti GAD positivity coexistence were higher (p=0.045, p=0.008, and p=0.007, respectively) among the patients diagnosed during the pandemic.

CONCLUSIONS:

We observed an increase in the number of patients newly diagnosed with type 1 diabetes mellitus, an increase in autoantibody positivity, and higher rates and severity of DKA during the COVID-19 pandemic period compared to the prepandemic period.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 1 / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: J Pediatr Endocrinol Metab Journal subject: Endocrinology / Pediatrics Year: 2021 Document Type: Article Affiliation country: Jpem-2021-0287

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Diabetes Mellitus, Type 1 / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adolescent / Child / Child, preschool / Humans / Infant / Male Country/Region as subject: Asia Language: English Journal: J Pediatr Endocrinol Metab Journal subject: Endocrinology / Pediatrics Year: 2021 Document Type: Article Affiliation country: Jpem-2021-0287