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SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway.
Saheb Sharif-Askari, Fatemeh; Saheb Sharif-Askari, Narjes; Goel, Swati; Hafezi, Shirin; Assiri, Rasha; Al-Muhsen, Saleh; Hamid, Qutayba; Halwani, Rabih.
  • Saheb Sharif-Askari F; Sharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
  • Saheb Sharif-Askari N; Sharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
  • Goel S; Sharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
  • Hafezi S; Sharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates.
  • Assiri R; Department of Basic Science, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Al-Muhsen S; Immunology Research Lab, Department of Pediatrics, College of Medicine, King Saud University, Saudi Arabia; Department of Pediatrics, College of Medicine, King Saud University, Saudi Arabia.
  • Hamid Q; Sharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Meakins-Christie Laboratories, Research Institute of the McGill University Health Center, Montreal,
  • Halwani R; Sharjah Institute of Medical Research, University of Sharjah, Sharjah, United Arab Emirates; Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Prince Abdullah Ben Khaled Celiac Disease Chair, Department of Pediatrics, Faculty of Medicine, Kin
Eur J Pharmacol ; 908: 174374, 2021 Oct 05.
Article in English | MEDLINE | ID: covidwho-1322083
ABSTRACT
The efficacy of corticosteroids and its use for the treatment of SARS-CoV-2 infections is controversial. In this study, using data sets of SARS-CoV-2 infected lung tissues and nasopharyngeal swabs, as well as in vitro experiments, we show that SARS-CoV-2 infection significantly downregulates DUSP1 expression. This downregulation of DUSP1 could be the mechanism regulating the enhanced activation of MAPK pathway as well as the reported steroid resistance in SARS-CoV-2 infection. Moreover, chloroquine, an off labeled COVID-19 drug is able to induce DUSP1 and attenuate MAPK pathway; and is expected to improve sensitivity to steroid treatment. However, further mechanistic studies are required to confirm this effect.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chloroquine / P38 Mitogen-Activated Protein Kinases / Dual Specificity Phosphatase 1 / COVID-19 Drug Treatment / Glucocorticoids Type of study: Observational study Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Eur J Pharmacol Year: 2021 Document Type: Article Affiliation country: J.ejphar.2021.174374

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Chloroquine / P38 Mitogen-Activated Protein Kinases / Dual Specificity Phosphatase 1 / COVID-19 Drug Treatment / Glucocorticoids Type of study: Observational study Limits: Adult / Aged / Humans / Middle aged Language: English Journal: Eur J Pharmacol Year: 2021 Document Type: Article Affiliation country: J.ejphar.2021.174374