"SARS-CoV-2 Infection in Liver Transplant Recipients - Immunosuppression is the Silver Lining?"
J Clin Exp Hepatol
; 12(2): 384-389, 2022.
Article
in English
| MEDLINE | ID: covidwho-1322188
ABSTRACT
BACKGROUND:
COVID-19 is associated with higher mortality among patients who have comorbidities. However, evidences related to COVID-19 among post liver transplant recipients are scarce and evolving.METHODS:
Adult Indian patients who had undergone liver transplantation at our centre since 2006 and were under regular follow-up, were contacted either telephonically or on email. Data were recorded related to symptoms and diagnosis of COVID-19, need for hospitalization, and need for ICU stay and mortality.RESULTS:
Eighty one (3.71%) of the 2182 adult Liver transplant (LT) recipients on regular follow-up reported SARS-CoV-2 infection between 1st April 2020 and 31st May 2021. Mean age was 51.3(±9.8) years, and 74(91.4%) were males. Thirty five (43.2%) patients had one or more comorbidities. Twenty one (25.9%) patients were transplanted less than 1 year ago. Forty four (54.3% ) patients had mild disease only while 23(28.4%) patients had severe COVID-19 disease. Of the 81 patients 14 patients died and overall mortality was 17.3.CONCLUSION:
Uncomplicated liver transplant recipients without comorbidities who acquire SARS-CoV-2 do not have poor outcome.
ARDS, Acute respiratory distress syndrome; CAD, Coronary artery disease; CKD, Chronic kidney disease; CNIs, Calcineurin inhibitors; COVID-19; COVID-19, corona virus disease 2019; LDLT, live donor liver transplants; LT, Liver transplant; NAAT, nucleic acid amplification test; NAFLD, Nonalcoholic fatty liver disease; NASH, Nonalcoholic steatohepatitis; OPD, Outpatients department; SARS-CoV-2, severe acute respiratory syndrome corona virus-2; liver transplant
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Prognostic study
Language:
English
Journal:
J Clin Exp Hepatol
Year:
2022
Document Type:
Article
Affiliation country:
J.jceh.2021.07.005
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