Neurological manifestations of COVID-19: A comprehensive literature review and discussion of mechanisms.
J Neuroimmunol
; 358: 577658, 2021 09 15.
Article
in English
| MEDLINE | ID: covidwho-1322224
ABSTRACT
Several neurological symptoms and complications have been described in association with COVID-19, such as anosmia, ageusia, encephalitis and Guillain-Barré syndrome. Here, we review the literature describing SARS-CoV-2-induced neurological manifestations and provide a comprehensive discussion of proposed mechanisms underlying the neurological pathophysiology. First, we analyse the neuroinvasiveness potential of the coronavirus family based on previous SARS-CoV-1 studies. Then, we describe the current evidence on COVID-19-induced nervous tissue damage, including processes behind brain vasculopathy and cytokine storm. We also discuss in detail anosmia and Guillain-Barré syndrome. Finally, we provide a summarised timeline of the main findings in the field. Future perspectives are presented, and suggestions of further investigations to clarify how SARS-COV-2 can affect the CNS.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Brain
/
SARS-CoV-2
/
COVID-19
/
Nervous System Diseases
Type of study:
Diagnostic study
/
Reviews
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
English
Journal:
J Neuroimmunol
Year:
2021
Document Type:
Article
Affiliation country:
J.jneuroim.2021.577658
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