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Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study.
Bal, Antonin; Brengel-Pesce, Karen; Gaymard, Alexandre; Quéromès, Grégory; Guibert, Nicolas; Frobert, Emilie; Bouscambert, Maude; Trabaud, Mary-Anne; Allantaz-Frager, Florence; Oriol, Guy; Cheynet, Valérie; d'Aubarede, Constance; Massardier-Pilonchery, Amélie; Buisson, Marlyse; Lupo, Julien; Pozzetto, Bruno; Poignard, Pascal; Lina, Bruno; Fassier, Jean-Baptiste; Morfin, Florence; Trouillet-Assant, Sophie.
  • Bal A; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
  • Brengel-Pesce K; CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.
  • Gaymard A; Joint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.
  • Quéromès G; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
  • Guibert N; CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.
  • Frobert E; CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.
  • Bouscambert M; Université Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
  • Trabaud MA; Occupational Health and Medicine Department, Hospices Civils de Lyon, Lyon, France.
  • Allantaz-Frager F; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
  • Oriol G; CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.
  • Cheynet V; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
  • d'Aubarede C; CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, 69007, Lyon, France.
  • Massardier-Pilonchery A; Laboratoire de Virologie, Institut des Agents Infectieux, Laboratoire associé au Centre National de Référence des virus des infections respiratoires, Hospices Civils de Lyon, Lyon, France.
  • Buisson M; Open Innovation and Partnerships (OIP), bioMérieux S.A., 69280, Marcy l'Etoile, France.
  • Lupo J; Joint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.
  • Pozzetto B; Joint Research Unit Hospices Civils de Lyon-bioMérieux, Lyon Sud Hospital, Pierre-Bénite, France.
  • Poignard P; Université Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
  • Lina B; Occupational Health and Medicine Department, Hospices Civils de Lyon, Lyon, France.
  • Fassier JB; Université Claude Bernard Lyon1, Ifsttar, UMRESTTE, UMR T_9405, Lyon University, 8 Avenue Rockefeller, Lyon, France.
  • Morfin F; Occupational Health and Medicine Department, Hospices Civils de Lyon, Lyon, France.
  • Trouillet-Assant S; Institut de Biologie Structurale, CEA, CNRS and Centre Hospitalier Universitaire Grenoble Alpes, Université Grenoble Alpes, Grenoble, France.
Sci Rep ; 11(1): 14977, 2021 07 22.
Article in English | MEDLINE | ID: covidwho-1322500
ABSTRACT
A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs (p = 0.07). The proportion of HCWs with a viral load > 5.0 log10 cp/mL (Ct value < 25) was less than 15% at 8 days after symptom onset; 12% of HCWs were positive after 40 days (Ct > 37). More than 90% of cultivable virus had a viral load > 4.5 log10 cp/mL (Ct < 26) and were collected within 10 days after symptom onset. Among negative HCWs, 6/190 (3.2%) seroconverted. Our data suggest that the determination of viral load can be used for appreciating the infectiousness of infected HCWs. These data could be helpful for facilitating their return to work.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-93828-y

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Health Personnel / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Sci Rep Year: 2021 Document Type: Article Affiliation country: S41598-021-93828-y