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COVID-19 in children with haematological malignancies.
Millen, Gerard Cathal; Arnold, Roland; Cazier, Jean-Baptiste; Curley, Helen; Feltbower, Richard; Gamble, Ashley; Glaser, Adam; Grundy, Richard G; Kirton, Laura; Lee, Lennard Y W; McCabe, Martin G; Palles, Claire; Phillips, Bob; Stiller, Charles A; Varnai, Csilla; Kearns, Pamela.
  • Millen GC; Cancer Research UK Clinical Trials Unit, University of Birmingham Institute of Cancer and Genomic Sciences, Birmingham, UK g.millen@nhs.net.
  • Arnold R; Department of Paediatric Oncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
  • Cazier JB; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Curley H; Centre for Computational Biology, University of Birmingham, Birmingham, UK.
  • Feltbower R; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Gamble A; Leeds Institute for Data Analytics (LIDA), University of Leeds School of Medicine, Leeds, West Yorkshire, UK.
  • Glaser A; CCLG Executive, Children's Cancer and Leukaemia Group, Leicester, UK.
  • Grundy RG; Leeds Institute for Data Analytics (LIDA), University of Leeds School of Medicine, Leeds, West Yorkshire, UK.
  • Kirton L; Leeds Institute of Medical Research, University of Leeds, Leeds, West Yorkshire, UK.
  • Lee LYW; CCLG Executive, Children's Cancer and Leukaemia Group, Leicester, UK.
  • McCabe MG; School of Medicine, University of Nottingham Children's Brain Tumour Research Centre, Nottingham, UK.
  • Palles C; Cancer Research UK Clinical Trials Unit, University of Birmingham Institute of Cancer and Genomic Sciences, Birmingham, UK.
  • Phillips B; Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
  • Stiller CA; Department of Oncology, University of Oxford, Oxford, Oxfordshire, UK.
  • Varnai C; Division of Cancer Sciences, The University of Manchester, Manchester, UK.
  • Kearns P; National Cancer Registration and Analysis Service, Public Health England, London, UK.
Arch Dis Child ; 107(2): 186-188, 2022 02.
Article in English | MEDLINE | ID: covidwho-1322772
ABSTRACT

BACKGROUND:

Children with cancer are not at increased risk of severe SARS-CoV-2 infection; however, adults with haematological malignancies have increased risk of severe infections compared with non-haematological malignancies.

METHODS:

We compared patients with haematological and non-haematological malignancies enrolled in the UK Paediatric Coronavirus Cancer Monitoring Project between 12 March 2020 and 16 February 2021. Children who received stem cell transplantation were excluded.

RESULTS:

Only 2/62 patients with haematological malignancy had severe/critical infections, with an OR of 0.5 for patients with haematological compared with non-haematological malignancies.

INTERPRETATION:

Children with haematological malignancies are at no greater risk of severe SARS-CoV-2 infection than those with non-haematological malignancies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Hematologic Neoplasms / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Arch Dis Child Year: 2022 Document Type: Article Affiliation country: Archdischild-2021-322062

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severity of Illness Index / Hematologic Neoplasms / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Arch Dis Child Year: 2022 Document Type: Article Affiliation country: Archdischild-2021-322062