SARS-CoV-2 Neutralization Resistance Mutations in Patient with HIV/AIDS, California, USA.

Hoffman, Seth A; Costales, Cristina; Sahoo, Malaya K; Palanisamy, Srikanth; Yamamoto, Fumiko; Huang, ChunHong; Verghese, Michelle; Solis, Daniel A; Sibai, Mamdouh; Subramanian, Aruna; Tompkins, Lucy S; Grant, Philip; Shafer, Robert W; Pinsky, Benjamin A

Hoffman, Seth A; Costales, Cristina; Sahoo, Malaya K; Palanisamy, Srikanth; Yamamoto, Fumiko; Huang, ChunHong; Verghese, Michelle; Solis, Daniel A; Sibai, Mamdouh; Subramanian, Aruna; Tompkins, Lucy S; Grant, Philip; Shafer, Robert W; Pinsky, Benjamin A.

Emerg Infect Dis ; 27(10): 2720-2723, 2021.

Article in English | MEDLINE | ID: covidwho-1486743

ABSTRACT

ABSTRACT

We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.

Subject(s)

Acquired Immunodeficiency Syndrome; COVID-19; Humans; Mutation; Protein Binding; SARS-CoV-2; Spike Glycoprotein, Coronavirus/genetics

Keywords

2019 novel coronavirus disease; COVID-19; California; HIV/AIDS; SARS-CoV-2; United States; antimicrobial resistance; coronavirus disease; coronaviruses; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; viral evolution; viruses; zoonoses

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Acquired Immunodeficiency Syndrome / COVID-19 Topics: Variants Limits: Humans Language: English Journal: Emerg Infect Dis Journal subject: Communicable Diseases Year: 2021 Document Type: Article

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