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Role of Multifunctional Cytoskeletal Filaments in Coronaviridae Infections: Therapeutic Opportunities for COVID-19 in a Nutshell.
Norris, Victor; Ovádi, Judit.
  • Norris V; Laboratory of Microbiology Signals and Microenvironment, University of Rouen, 76821 Mont Saint Aignan, France.
  • Ovádi J; Institute of Enzymology, Research Centre for Natural Sciences, ELKH 1117 Budapest, Hungary.
Cells ; 10(7)2021 07 19.
Article in English | MEDLINE | ID: covidwho-1323131
ABSTRACT
A novel coronavirus discovered in 2019 is a new strain of the Coronaviridae family (CoVs) that had not been previously identified in humans. It is known as SARS-CoV-2 for Severe Acute Respiratory Syndrome Coronavirus-2, whilst COVID-19 is the name of the disease associated with the virus. SARS-CoV-2 emerged over one year ago and still haunts the human community throughout the world, causing both healthcare and socioeconomic problems. SARS-CoV-2 is spreading with many uncertainties about treatment and prevention the data available are limited and there are few randomized controlled trial data on the efficacy of antiviral or immunomodulatory agents. SARS-CoV-2 and its mutants are considered as unique within the Coronaviridae family insofar as they spread rapidly and can have severe effects on health. Although the scientific world has been succeeding in developing vaccines and medicines to combat COVID-19, the appearance and the spread of new, more aggressive mutants are posing extra problems for treatment. Nevertheless, our understanding of pandemics is increasing significantly due to this outbreak and is leading to the development of many different pharmacological, immunological and other treatments. This Review focuses on a subset of COVID-19 research, primarily the cytoskeleton-related physiological and pathological processes in which coronaviruses such as SARS-CoV-2 are intimately involved. The discovery of the exact mechanisms of the subversion of host cells by SARS-CoV-2 is critical to the validation of specific drug targets and effective treatments.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Cytoskeleton / Coronaviridae Infections / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10071818

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Cytoskeleton / Coronaviridae Infections / COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals / Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10071818