Pregnancy and pandemics: Interaction of viral surface proteins and placenta cells.
Biochim Biophys Acta Mol Basis Dis
; 1867(11): 166218, 2021 11 01.
Article
in English
| MEDLINE | ID: covidwho-1323748
ABSTRACT
Throughout history, pandemics of infectious diseases caused by emerging viruses have spread worldwide. Evidence from previous outbreaks demonstrated that pregnant women are at high risk of contracting the diseases and suffering from adverse outcomes. However, while some viruses can cause major health complications for the mother and her fetus, others do not appear to affect pregnancy. Viral surface proteins bind to specific receptors on the cellular membrane of host cells and begin therewith the infection process. During pregnancy, the molecular features of these proteins may determine specific target cells in the placenta, which may explain the different outcomes. In this review, we display information on Variola, Influenza, Zika and Corona viruses focused on their surface proteins, effects on pregnancy, and possible target placental cells. This will contribute to understanding viral entry during pregnancy, as well as to develop strategies to decrease the incidence of obstetrical problems in current and future infections.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Placenta
/
Pregnancy Complications, Infectious
/
Virus Diseases
/
Viral Envelope Proteins
Type of study:
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Biochim Biophys Acta Mol Basis Dis
Year:
2021
Document Type:
Article
Affiliation country:
J.bbadis.2021.166218
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