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Personalized health and the coronavirus vaccines-Do individual genetics matter?
Valdés-Fernández, Bianca N; Duconge, Jorge; Espino, Ana M; Ruaño, Gualberto.
  • Valdés-Fernández BN; Department of Microbiology, School of Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.
  • Duconge J; Department of Biology, University of Puerto Rico Rio Piedras Campus, San Juan, Puerto Rico, USA.
  • Espino AM; Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico - Medical Sciences Campus, San Juan, Puerto Rico, USA.
  • Ruaño G; Department of Microbiology, School of Medicine, University of Puerto Rico-Medical Sciences Campus, San Juan, Puerto Rico, USA.
Bioessays ; 43(9): e2100087, 2021 09.
Article in English | MEDLINE | ID: covidwho-1323859
ABSTRACT
Vaccines represent preventative interventions amenable to immunogenetic prediction of how human variability will influence their safety and efficacy. The genetic polymorphism among individuals within any population can render possible that the immunity elicited by a vaccine is variable in length and strength. The same immune challenge (virus and/or vaccine) could provoke partial, complete or even failed protection for some individuals treated under the same conditions. We review genetic variants and mechanistic relationships among chemokines, chemokine receptors, interleukins, interferons, interferon receptors, toll-like receptors, histocompatibility antigens, various immunoglobulins and major histocompatibility complex antigens. These are the targets for variation among macrophages, dendritic cells, natural killer cells, T- and B-lymphocytes, and complement. The technology platforms (mRNA, viral vectors, proteins) utilized to produce vaccines against SARS-CoV-2 infections may each trigger genetically distinct immune reactogenic profiles. With DNA biobanking and immunoprofiling of recipients, global COVID-19 vaccinations could launch a new era of personalized healthcare.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Bioessays Journal subject: Biology / Molecular Biology Year: 2021 Document Type: Article Affiliation country: Bies.202100087

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Vaccines / COVID-19 Type of study: Prognostic study Topics: Vaccines / Variants Limits: Humans Language: English Journal: Bioessays Journal subject: Biology / Molecular Biology Year: 2021 Document Type: Article Affiliation country: Bies.202100087