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Tissue Lipidomic Alterations Induced by Prolonged Dexamethasone Treatment.
Buzatto, Adriana Zardini; Malkawi, Abeer; Sabi, Essa M; Mujamammi, Ahmed H; Li, Liang; Abdel Rahman, Anas M.
  • Buzatto AZ; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
  • Malkawi A; Department of Chemistry, University of Quebec at Montreal, Montreal, QC H3C3P8, Canada.
  • Sabi EM; Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh 11211, Saudi Arabia.
  • Mujamammi AH; Clinical Biochemistry Unit, Department of Pathology, College of Medicine, King Saud University, Riyadh 11211, Saudi Arabia.
  • Li L; Department of Chemistry, University of Alberta, Edmonton, AB T6G 2R3, Canada.
  • Abdel Rahman AM; Metabolomics Section, Clinical Genomics, Center for Genomics Medicine, King Faisal Specialist Hospital and Research Centre (KFSHRC), Zahrawi Street, Al Maather, Riyadh 11211, Saudi Arabia.
J Proteome Res ; 20(3): 1558-1570, 2021 03 05.
Article in English | MEDLINE | ID: covidwho-1324404
ABSTRACT
Dexamethasone is a synthetic glucocorticoid medication vastly used to treat abnormal immune responses and inflammation. Although the medication is well-established in the medical community, the prolonged treatment with high dosages of dexamethasone may lead to severe adverse effects through mechanisms that are not yet well-known. Lipids are a large class of hydrophobic molecules involved in energy storage, signaling, modulation of gene expression, and membranes. Hence, untargeted lipidomics may help unravel the biochemical alterations following prolonged treatment with high dosages of dexamethasone. We performed comprehensive lipidomic analyses of brain, heart, kidney, liver, and muscle samples obtained from rats that were treated with intramuscular injections of dexamethasone for 14 weeks compared to healthy controls. The employed methodology and statistical analysis showed that phosphatidic acids, glycerophospholipids, plasmalogens, and fatty acids are deeply affected by prolonged use of the medication. Brain tissue was only mildly affected, but skeletal muscle showed a strong accumulation of lipids that may be correlated with alterations in the energy metabolism, myopathy, and oxidative processes. This work provides new insights into the mechanisms of action and adverse effects for one of the most commonly prescribed class of drugs in the world.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lipidomics / Lipids Limits: Animals Language: English Journal: J Proteome Res Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: Acs.jproteome.0c00759

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Lipidomics / Lipids Limits: Animals Language: English Journal: J Proteome Res Journal subject: Biochemistry Year: 2021 Document Type: Article Affiliation country: Acs.jproteome.0c00759