Expression of SARS-CoV-2 receptor "ACE2" in human pancreatic ß cells: to be or not to be!
Islets
; 13(5-6): 106-114, 2021 09 03.
Article
in English
| MEDLINE | ID: covidwho-1324536
ABSTRACT
The current COVID-19 pandemic, which continues to spread across the globe, is caused by severe acute respiratory syndrome coronavirus (SARS-Cov-2). Soon after the pandemic emerged in China, it became clear that the receptor-binding domain (RBD) of angiotensin-converting enzyme 2 (ACE2) serves as the primary cell surface receptor for SARS-Cov-2. Subsequent work has shown that diabetes and hyperglycemia are major risk factors for morbidity and mortality in COVID-19 patients. However, data on the pattern of expression of ACE2 on human pancreatic ß cells remain contradictory. Additionally, there is no consensus on whether the virus can directly infect and damage pancreatic islets and hence exacerbate diabetes. In this mini-review, we highlight the role of ACE2 receptor and summarize the current state of knowledge regarding its expression/co-localization in human pancreatic endocrine cells. We also discuss recent data on the permissiveness of human pancreatic ß cells to SARS-Cov-2 infection.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Insulin-Secreting Cells
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Islets
Journal subject:
Endocrinology
/
Gastroenterology
Year:
2021
Document Type:
Article
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