Obesity as a multisystem disease: Trends in obesity rates and obesity-related complications.
Diabetes Obes Metab
; 23 Suppl 1: 3-16, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-1324985
ABSTRACT
Obesity is a chronic multisystem disease associated with increased morbidity and mortality. The increasing prevalence of obesity makes it a major healthcare challenge across both developed and developing countries. Traditional measures such as body mass index do not always identify individuals at increased risk of comorbidities, yet continue to be used in deciding who qualifies for weight loss treatment. A better understanding of how obesity is associated with comorbidities, in particular non-metabolic conditions, is needed to identify individuals at risk in order to prioritize treatment. For metabolic disorders such as type 2 diabetes (T2D), weight loss can prevent T2D in individuals with prediabetes. It can improve and reverse T2D if weight loss is achieved early in the course of the disease. However, access to effective weight loss treatments is a significant barrier to improved health for people with obesity. In the present paper, we review the rising prevalence of obesity and why it should be classed as a multisystem disease. We will discuss potential mechanisms underlying its association with various comorbidities and how these respond to treatment, with a particular focus on cardiometabolic disease, malignancy and mental health.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Prediabetic State
/
Diabetes Mellitus, Type 2
/
Bariatric Surgery
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Diabetes Obes Metab
Journal subject:
Endocrinology
/
Metabolism
Year:
2021
Document Type:
Article
Affiliation country:
Dom.14290
Similar
MEDLINE
...
LILACS
LIS