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Unified platform for genetic and serological detection of COVID-19 with single-molecule technology.
Furth, Noa; Shilo, Shay; Cohen, Niv; Erez, Nir; Fedyuk, Vadim; Schrager, Alexander M; Weinberger, Adina; Dror, Amiel A; Zigron, Asaf; Shehadeh, Mona; Sela, Eyal; Srouji, Samer; Amit, Sharon; Levy, Itzchak; Segal, Eran; Dahan, Rony; Jones, Dan; Douek, Daniel C; Shema, Efrat.
  • Furth N; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Shilo S; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Cohen N; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Erez N; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Fedyuk V; Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.
  • Schrager AM; Human Immunology Section, Vaccine Research Center, National Institutes of Health, Bethesda, MD, United States of America.
  • Weinberger A; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.
  • Dror AA; Department of Otolaryngology, Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel.
  • Zigron A; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Shehadeh M; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Sela E; Oral and Maxillofacial Department, Galilee Medical Center, Nahariya, Israel.
  • Srouji S; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Amit S; Clinical Laboratories Division, Clinical Biochemistry and Endocrinology Laboratory, Galilee Medical Center, Naharia, Israel.
  • Levy I; Department of Otolaryngology, Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel.
  • Segal E; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Dahan R; The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Jones D; Oral and Maxillofacial Department, Galilee Medical Center, Nahariya, Israel.
  • Douek DC; Sheba Medical Center, Ramat Gan, Israel.
  • Shema E; Sheba Medical Center, Ramat Gan, Israel.
PLoS One ; 16(7): e0255096, 2021.
Article in English | MEDLINE | ID: covidwho-1325440
Preprint
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ABSTRACT
The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients' samples, as well as their immune response consisting of IgG and IgM antibodies. Thus, it establishes a platform for diagnostics of COVID-19, which could also be adjusted to diagnose additional pathogens.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Single Molecule Imaging / COVID-19 Nucleic Acid Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0255096

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Viral Proteins / Single Molecule Imaging / COVID-19 Nucleic Acid Testing / COVID-19 Serological Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study Limits: Humans Language: English Journal: PLoS One Journal subject: Science / Medicine Year: 2021 Document Type: Article Affiliation country: Journal.pone.0255096