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From COVID-19 to Cancer mRNA Vaccines: Moving From Bench to Clinic in the Vaccine Landscape.
Chakraborty, Chiranjib; Sharma, Ashish Ranjan; Bhattacharya, Manojit; Lee, Sang-Soo.
  • Chakraborty C; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, India.
  • Sharma AR; Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-do, South Korea.
  • Bhattacharya M; Institute for Skeletal Aging & Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon, Gangwon-do, South Korea.
  • Lee SS; Department of Zoology, Fakir Mohan University, Odisha, India.
Front Immunol ; 12: 679344, 2021.
Article in English | MEDLINE | ID: covidwho-1325528
ABSTRACT
Recently, mRNA vaccines have become a significant type of therapeutic and have created new fields in the biopharmaceutical industry. mRNA vaccines are promising next-generation vaccines that have introduced a new age in vaccinology. The recent approval of two COVID-19 mRNA vaccines (mRNA-1273 and BNT162b2) has accelerated mRNA vaccine technology and boosted the pharmaceutical and biotechnology industry. These mRNA vaccines will help to tackle COVID-19 pandemic through immunization, offering considerable hope for future mRNA vaccines. Human trials with data both from mRNA cancer vaccines and mRNA infectious disease vaccines have provided encouraging results, inspiring the pharmaceutical and biotechnology industries to focus on this area of research. In this article, we discuss current mRNA vaccines broadly in two parts. In the first part, mRNA vaccines in general and COVID-19 mRNA vaccines are discussed. We presented the mRNA vaccine structure in general, the different delivery systems, the immune response, and the recent clinical trials for mRNA vaccines (both for cancer mRNA vaccines and different infectious diseases mRNA vaccines). In the second part, different COVID-19 mRNA vaccines are explained. Finally, we illustrated a snapshot of the different leading mRNA vaccine developers, challenges, and future prospects of mRNA vaccines.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines, Synthetic / Cancer Vaccines / Drug Development / COVID-19 Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.679344

Full text: Available Collection: International databases Database: MEDLINE Main subject: Vaccines, Synthetic / Cancer Vaccines / Drug Development / COVID-19 Vaccines Limits: Humans Language: English Journal: Front Immunol Year: 2021 Document Type: Article Affiliation country: Fimmu.2021.679344