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The Role of Alveolar Edema in COVID-19.
Yuan, Shu; Jiang, Si-Cong; Zhang, Zhong-Wei; Fu, Yu-Fan; Hu, Jing; Li, Zi-Lin.
  • Yuan S; College of Resources, Sichuan Agricultural University, Chengdu 611130, China.
  • Jiang SC; Chengdu Kang Hong Pharmaceutical Group Comp. Ltd., Chengdu 610036, China.
  • Zhang ZW; College of Resources, Sichuan Agricultural University, Chengdu 611130, China.
  • Fu YF; College of Resources, Sichuan Agricultural University, Chengdu 611130, China.
  • Hu J; School of Medicine, Northwest University, Xi'an 710069, China.
  • Li ZL; Department of Cardiovascular Surgery, Xijing Hospital, Medical University of the Air Force, Xi'an 710032, China.
Cells ; 10(8)2021 07 26.
Article in English | MEDLINE | ID: covidwho-1325607
ABSTRACT
The coronavirus disease 2019 (COVID-19) has spread over the world for more than one year. COVID-19 often develops life-threatening hypoxemia. Endothelial injury caused by the viral infection leads to intravascular coagulation and ventilation-perfusion mismatch. However, besides above pathogenic mechanisms, the role of alveolar edema in the disease progression has not been discussed comprehensively. Since the exudation of pulmonary edema fluid was extremely serious in COVID-19 patients, we bring out a hypothesis that severity of alveolar edema may determine the size of poorly-ventilated area and the blood oxygen content. Treatments to pulmonary edema (conservative fluid management, exogenous surfactant replacements and ethanol-oxygen vapor therapy hypothetically) may be greatly helpful for reducing the occurrences of severe cases. Given that late mechanical ventilation may cause mucus (edema fluid) to be blown deep into the small airways, oxygen therapy should be given at the early stages. The optimal time and blood oxygen saturation (SpO2) threshold for oxygen therapy are also discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Alveoli / Edema / COVID-19 Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10081897

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Alveoli / Edema / COVID-19 Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10081897