Omega-3 Index and Clinical Outcomes of Severe COVID-19: Preliminary Results of a Cross-Sectional Study.
Int J Environ Res Public Health
; 18(15)2021 07 21.
Article
in English
| MEDLINE | ID: covidwho-1325644
ABSTRACT
The potentially detrimental effects of the worldwide deficiency of Omega-3 fatty acids on the COVID-19 pandemic have been underestimated. The Omega-3 Index (O3I), clinical variables, biometric indices, and nutritional information were directly determined for 74 patients with severe COVID-19 and 10 healthy quality-control subjects. The relationships between the OI3 and mechanical ventilation (MV) and death were analyzed. Results:
Patients with COVID-19 exhibited low O3I (mean 4.15%; range 3.06-6.14%)-consistent with insufficient fish and Omega-3 supplement consumption, and markedly lower than the healthy control subjects (mean 7.84%; range 4.65-10.71%). Inverse associations were observed between O3I and MV (OR = 0.459; C.I. 0.211-0.997) and death (OR = 0.28; C.I. 0.08-0.985) in severe COVID-19, even after adjusting for sex, age, and well-known risk factors.Conclusion:
We present preliminary evidence to support the hypothesis that the risk of severe COVID-19 can be stratified by the O3I quartile. Further investigations are needed to assess the value of the O3I as a blood marker for COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Fatty Acids, Omega-3
/
COVID-19
Type of study:
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Animals
/
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Ijerph18157722
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