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Hospitalisation for Drug Infusion Did Not Increase Levels of Anxiety and the Risk of Disease Relapse in Patients with Inflammatory Bowel Disease during COVID-19 Outbreak.
Bertani, Lorenzo; Barberio, Brigida; Tricò, Domenico; Zanzi, Federico; Maniero, Daria; Ceccarelli, Linda; Marsilio, Ilaria; Coppini, Francesca; Lorenzon, Greta; Mumolo, Maria Gloria; Zingone, Fabiana; Costa, Francesco; Savarino, Edoardo Vincenzo.
  • Bertani L; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56100 Pisa, Italy.
  • Barberio B; Department of Surgery, Tuscany North-West ASL, Massa Apuane Hospital, 54100 Massa, Italy.
  • Tricò D; Department of Surgery, Oncology and Gastroenterology, DISCOG, University of Padua, 35100 Padua, Italy.
  • Zanzi F; Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, 56100 Pisa, Italy.
  • Maniero D; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56100 Pisa, Italy.
  • Ceccarelli L; Department of Surgery, Oncology and Gastroenterology, DISCOG, University of Padua, 35100 Padua, Italy.
  • Marsilio I; Department of General Surgery and Gastroenterology, IBD Unit, Pisa University Hospital, 56124 Pisa, Italy.
  • Coppini F; Department of Surgery, Oncology and Gastroenterology, DISCOG, University of Padua, 35100 Padua, Italy.
  • Lorenzon G; Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, 56100 Pisa, Italy.
  • Mumolo MG; Department of Surgery, Oncology and Gastroenterology, DISCOG, University of Padua, 35100 Padua, Italy.
  • Zingone F; Department of General Surgery and Gastroenterology, IBD Unit, Pisa University Hospital, 56124 Pisa, Italy.
  • Costa F; Department of Surgery, Oncology and Gastroenterology, DISCOG, University of Padua, 35100 Padua, Italy.
  • Savarino EV; Department of General Surgery and Gastroenterology, IBD Unit, Pisa University Hospital, 56124 Pisa, Italy.
J Clin Med ; 10(15)2021 Jul 24.
Article in English | MEDLINE | ID: covidwho-1325715
ABSTRACT
During the coronavirus disease 2019 (COVID-19) pandemic, immunomodulatory therapies and hospital admission were suspected to increase the risk of infection. Nevertheless, patients with inflammatory bowel diseases (IBD) treated with intravenous (i.v.) biologics had to move to hospitals for drug infusion. We investigated the impact of hospitalisation in patients with IBD. We conducted a survey including consecutive IBD patients initially in clinical and biochemical remission treated with biologics at the end of the first lockdown period. Patients underwent the normally scheduled clinical visits, performed at hospital for i.v.-treated patients or at home for patients treated with s.c. drugs. We administered to all patients the Hospital Anxiety and Depression Scale (HADS) questionnaire and other 12 questions, specifically related to COVID-19 and its implications. A total of 189 IBD patients were recruited, 112 (59.3%) treated with i.v. drugs and 77 (40.7%) with s.c. ones. No relapses were recorded in either group (hospitalized vs. non-hospitalized, p = ns), as well as which, COVID-19 infections were not demonstrated in patients in contact with people with suspected symptoms or directly experiencing them. The total HADS score obtained by the sum of all items was also almost identical between groups (37.1 ± 2.8 vs. 37.2 ± 2.8; p = 0.98). In patients treated with i.v. drugs receiving a televisit (n = 17), the rate of satisfaction with telemedicine (58.8%) was significantly lower compared with those treated with s.c. drugs (94.8%; p < 0.0005). Our results suggest that hospitalisation during the COVID-19 outbreak does not increase the risk of COVID-19 infection as well as the risk of IBD relapse; moreover, the similar levels of anxiety in both groups could confirm that there is no need to convert patients from i.v. to s.c. therapy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10153270

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Year: 2021 Document Type: Article Affiliation country: Jcm10153270