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Evaluation of the relationship between pentraxin 3 (PTX3) rs2305619 (281A/G) and rs1840680 (1449A/G) polymorphisms and the clinical course of COVID-19.
Kerget, Ferhan; Kerget, Bugra; Kahraman, Çigdem Yüce; Araz, Ömer; Akgün, Metin; Uçar, Elif Yilmazel; Saglam, Leyla.
  • Kerget F; Depertmant of Infection Diseases and Clinical Microbiology, Erzurum Regional Education and Research Hospital, Health Sciences University, Erzurum, Turkey.
  • Kerget B; Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey.
  • Kahraman ÇY; Department of Medical Genetic, Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey.
  • Araz Ö; Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey.
  • Akgün M; Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey.
  • Uçar EY; Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey.
  • Saglam L; Department of Pulmonary Diseases, Ataturk University School of Medicine, Erzurum, Yakutiye, Turkey.
J Med Virol ; 93(12): 6653-6659, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1530185
ABSTRACT
Macrophage activation syndrome (MAS) is one of the main causes of morbidity and mortality in patients with coronavirus disease 2019 (COVID-19). This study aimed to investigate the relationship between the pentraxin 3 (PTX3) gene polymorphisms rs2305619 (281A/G) and rs1840680 (1449A/G) and the development of MAS in patients with COVID-19. The study included a total of 94 patients aged 18-45 who were diagnosed as having COVID-19 between June and December 2020. PTX3 281A/G and 1449A/G polymorphism frequencies were evaluated. PTX3 281A/G allele and genotype frequencies did not deviate from Hardy-Weinberg (HW) equilibrium in the MAS or non-MAS group (χ2 0.049, df 2, p = 0.976, χ2 0.430, df 2, p = 0.806). PTX3 1449A/G allele and genotype frequencies deviated significantly from HW equilibrium in the non-MAS group (χ2 6.794, df 2, p = 0.033) but not in the MAS group (χ2 2.256, df 2, p = 0.324). The AG genotype was significantly more frequent in the non-MAS group, while the AA genotype was significantly more frequent in the MAS group (χ2 11.099, df 2, p= 0.004). Analysis of the PTX3 1449A/G polymorphism showed that individuals with the GG genotype had higher serum PTX3 levels than those with the AA and AG genotypes (p = 0.001 for both). Analysis of the PTX3 1449A/G polymorphism in patients with COVID-19 showed that those with the AG genotype were relatively more protected from MAS compared with individuals with the AA genotype. In addition, lower serum PTX3 levels are observed in patients carrying the A allele.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / Serum Amyloid P-Component / Polymorphism, Single Nucleotide / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27238

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Full text: Available Collection: International databases Database: MEDLINE Main subject: C-Reactive Protein / Serum Amyloid P-Component / Polymorphism, Single Nucleotide / COVID-19 Type of study: Experimental Studies / Prognostic study Limits: Adolescent / Adult / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Med Virol Year: 2021 Document Type: Article Affiliation country: Jmv.27238