Acute encephalitis, myoclonus and Sweet syndrome after mRNA-1273 vaccine.
BMJ Case Rep
; 14(7)2021 Jul 26.
Article
in English
| MEDLINE | ID: covidwho-1327622
ABSTRACT
A patient presented with fever, generalised rash, confusion, orofacial movements and myoclonus after receiving the first dose of mRNA-1273 vaccine from Moderna. MRI was unremarkable while cerebrospinal fluid showed leucocytosis with lymphocyte predominance and hyperproteinorrachia. The skin evidenced red, non-scaly, oedematous papules coalescing into plaques with scattered non-follicular pustules. Skin biopsy was consistent with a neutrophilic dermatosis. The patient fulfilled the criteria for Sweet syndrome. A thorough evaluation ruled out alternative infectious, autoimmune or malignant aetiologies, and all manifestations resolved with glucocorticoids. While we cannot prove causality, there was a temporal correlation between the vaccination and the clinical findings.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Sweet Syndrome
/
Encephalitis
/
Myoclonus
Type of study:
Case report
/
Diagnostic study
/
Etiology study
/
Experimental Studies
/
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
Bcr-2021-243173
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