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Delirium in COVID-19 patients: a multicentric observational study in Italy.
Martinotti, Giovanni; Bonanni, Laura; Barlati, Stefano; Miuli, Andrea; Sepede, Gianna; Prestia, Davide; Trabucco, Alice; Palumbo, Claudia; Massaro, Alessandra; Olcese, Martina; D'Ardes, Damiano; Cipollone, Francesco; Amore, Mario; Bondi, Emi; Russo, Mirella; Carrarini, Claudia; Onofrj, Marco; Sensi, Stefano Luca; Vita, Antonio; di Giannantonio, Massimo.
  • Martinotti G; Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.
  • Bonanni L; Department of Pharmacy, Pharmacology, Clinical Science, University of Hertfordshire, Hatfield, Herts, UK.
  • Barlati S; Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.
  • Miuli A; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
  • Sepede G; Department of Mental Health, ASL Lanciano-Vasto-Chieti, Viale Amendola 47, Chieti, Italy. andreamiuli@live.it.
  • Prestia D; Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.
  • Trabucco A; Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, Section of Psychiatry, University of Genoa, Genoa, Italy.
  • Palumbo C; Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, Section of Psychiatry, University of Genoa, Genoa, Italy.
  • Massaro A; Department of Psychiatry, Hospital Papa Giovanni XXIII, Bergamo, Italy.
  • Olcese M; Department of Psychiatry, Hospital Papa Giovanni XXIII, Bergamo, Italy.
  • D'Ardes D; Psychologist, Independent Researcher, Genoa, Italy.
  • Cipollone F; Department of Medicine and Aging Sciences, University G. D'Annunzio of Chieti-Pescara, Chieti, Italy.
  • Amore M; Department of Medicine and Aging Sciences, University G. D'Annunzio of Chieti-Pescara, Chieti, Italy.
  • Bondi E; Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, Section of Psychiatry, University of Genoa, Genoa, Italy.
  • Russo M; Department of Psychiatry, Hospital Papa Giovanni XXIII, Bergamo, Italy.
  • Carrarini C; Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.
  • Onofrj M; Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.
  • Sensi SL; Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.
  • Vita A; Department of Neuroscience, Imaging and Clinical Sciences, "G. D'Annunzio" University of Chieti, Chieti, Italy.
  • di Giannantonio M; Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Neurol Sci ; 42(10): 3981-3988, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1328622
ABSTRACT

INTRODUCTION:

Although recent data show that SARS-CoV-2 infection seems to affect the central nervous system (CNS), little is known about the neuropsychiatric effects resulting from this condition. In addition to the well-known neurotrophism of coronaviruses, recent evidence shows also that the "cytokine storm" induced by the infection is at the basis of the neuroinflammation of the CNS. Furthermore, prolonged hospitalization, polypharmacotherapy, and isolation could be at the basis of the onset of delirium in hospitalized COVID patients. This multicentric observational study explores the incidence of the onset of delirium in an Italian cohort of SARS-CoV-2 positive inpatients.

METHODS:

Data were collected in the COVIDhospitals of Brescia, Bergamo, Chieti, and Genova. Different socio-demographic, medical, neurological, and pharmacological parameters were collected. As a rapid screening for delirium, the 4AT scale was used. Eighty COVID-19 inpatients (mean age 74.7 ± 14.5 years) met the inclusion criteria (confirmed positivity to the SARS-CoV-2 virus; the presence of delirium and/or psychomotor agitation and/or new onset of other neuropsychiatric symptoms during hospitalization).

RESULTS:

The majority of these patients (68.8%) had "hyperactive delirium" subtype. Polypharmacotherapy, current treatment with corticosteroids, and higher age were associated with delirium severity.

CONCLUSION:

These data provide an insight into the onset of delirium among COVID-19 patients underlining the need for monitoring, especially in elderly patients, the neuropsychiatric symptoms, and the therapy in order to have shorter hospitalization times and better outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Delirium / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: S10072-021-05461-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Delirium / COVID-19 Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Aged / Humans / Middle aged Country/Region as subject: Europa Language: English Journal: Neurol Sci Journal subject: Neurology Year: 2021 Document Type: Article Affiliation country: S10072-021-05461-2