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The trans-omics landscape of COVID-19.
Wu, Peng; Chen, Dongsheng; Ding, Wencheng; Wu, Ping; Hou, Hongyan; Bai, Yong; Zhou, Yuwen; Li, Kezhen; Xiang, Shunian; Liu, Panhong; Ju, Jia; Guo, Ensong; Liu, Jia; Yang, Bin; Fan, Junpeng; He, Liang; Sun, Ziyong; Feng, Ling; Wang, Jian; Wu, Tangchun; Wang, Hao; Cheng, Jin; Xing, Hui; Meng, Yifan; Li, Yongsheng; Zhang, Yuanliang; Luo, Hongbo; Xie, Gang; Lan, Xianmei; Tao, Ye; Li, Jiafeng; Yuan, Hao; Huang, Kang; Sun, Wan; Qian, Xiaobo; Li, Zhichao; Huang, Mingxi; Ding, Peiwen; Wang, Haoyu; Qiu, Jiaying; Wang, Feiyue; Wang, Shiyou; Zhu, Jiacheng; Ding, Xiangning; Chai, Chaochao; Liang, Langchao; Wang, Xiaoling; Luo, Lihua; Sun, Yuzhe; Yang, Ying.
  • Wu P; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Chen D; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Ding W; BGI-Shenzhen, Shenzhen, China.
  • Wu P; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Hou H; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Bai Y; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Zhou Y; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li K; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Xiang S; BGI-Shenzhen, Shenzhen, China.
  • Liu P; BGI-Shenzhen, Shenzhen, China.
  • Ju J; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Guo E; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Liu J; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yang B; BGI-Shenzhen, Shenzhen, China.
  • Fan J; BGI-Shenzhen, Shenzhen, China.
  • He L; BGI-Shenzhen, Shenzhen, China.
  • Sun Z; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Feng L; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Wang J; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Wu T; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Wang H; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Cheng J; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Xing H; Department of Gynecologic Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Meng Y; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Li Y; Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China.
  • Zhang Y; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Luo H; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
  • Xie G; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Lan X; Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Tao Y; Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Li J; Department of Research, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei, China.
  • Yuan H; Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Hubei University of Arts and Science, Xiangyang, Hubei, China.
  • Huang K; Department of Gynecologic Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China.
  • Sun W; Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou, China.
  • Qian X; BGI-Shenzhen, Shenzhen, China.
  • Li Z; BGI-Shenzhen, Shenzhen, China.
  • Huang M; BGI-Guizhou, BGI-Shenzhen, Guiyang, China.
  • Ding P; BGI-Shenzhen, Shenzhen, China.
  • Wang H; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Qiu J; BGI-Shenzhen, Shenzhen, China.
  • Wang F; BGI-Shenzhen, Shenzhen, China.
  • Wang S; BGI-Shenzhen, Shenzhen, China.
  • Zhu J; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Ding X; BGI-Shenzhen, Shenzhen, China.
  • Chai C; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Liang L; BGI-Shenzhen, Shenzhen, China.
  • Wang X; BGI-Shenzhen, Shenzhen, China.
  • Luo L; BGI-Shenzhen, Shenzhen, China.
  • Sun Y; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Yang Y; BGI-Shenzhen, Shenzhen, China.
Nat Commun ; 12(1): 4543, 2021 07 27.
Article in English | MEDLINE | ID: covidwho-1328844
ABSTRACT
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 231 COVID-19 patients, prefiltered to exclude those with selected comorbidities, yet with symptoms ranging from asymptomatic to critically ill. Using integrative analysis of genomic, transcriptomic, proteomic, metabolomic and lipidomic profiles, we report a trans-omics landscape for COVID-19. Our analyses find neutrophils heterogeneity between asymptomatic and critically ill patients. Meanwhile, neutrophils over-activation, arginine depletion and tryptophan metabolites accumulation correlate with T cell dysfunction in critical patients. Our multi-omics data and characterization of peripheral blood from COVID-19 patients may thus help provide clues regarding pathophysiology of and potential therapeutic strategies for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-24482-1

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2021 Document Type: Article Affiliation country: S41467-021-24482-1