Relationship of D-dimer and prediction of pulmonary embolism in hospitalized COVID-19 patients: a multicenter study.
Future Microbiol
; 16: 863-870, 2021 08.
Article
in English
| MEDLINE | ID: covidwho-1329169
ABSTRACT
Aim:
COVID-19 is a known risk factor for pulmonary embolism (PE). In this retrospective, multicenter study, we aimed to determine an optimal D-dimer cutoff to predict PE in hospitalized patients with COVID-19. Materials &methods:
A total of 193 patients underwent computerized tomographic pulmonary angiography imaging and were classified into PE positive and negative groups. Physiological, radiological and biochemical parameters were compared and receiver operator curve analysis was conducted to determine a predictive D-dimer threshold.Results:
An optimal D-dimer cutoff of 2494 ng/ml was selected (Youden index 0.906), giving a sensitivity of 100% (95% CI 100-100) and specificity of 90.62% (95% CI 90.5-90.8) for predicting PE.Conclusion:
We propose that in the absence of other clinical signs, a D-dimer threshold of 2495 ng/ml could be used with high sensitivity and specificity to predict PE in hospitalized patients with COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pulmonary Embolism
/
Fibrin Fibrinogen Degradation Products
/
COVID-19
/
Lung
Type of study:
Diagnostic study
/
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
English
Journal:
Future Microbiol
Journal subject:
Microbiology
Year:
2021
Document Type:
Article
Affiliation country:
Fmb-2021-0082
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